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Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (3D class1 at 4.33A)

Electron Microscopy
4.33Å resolution
PDB entry 5ykf coloured by chain, front view.
PDB entry 5ykf coloured by chain, side view.
PDB entry 5ykf coloured by chain, top view.
Source organisms:
Assembly composition:
hetero octamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: ATP-sensitive inward rectifier potassium channel 11 and ATP-binding cassette sub-family C member 8 isoform X2
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Multimeric state: hetero octamer
Accessible surface area: 295790.28 Å2
Buried surface area: 39636.4 Å2
Dissociation area: 5,043.34 Å2
Dissociation energy (ΔGdiss): 40.72 kcal/mol
Dissociation entropy (TΔSdiss): 69.6 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-103767

Macromolecules

ATP-sensitive inward rectifier potassium channel 11
Chains: A, C, E, G
Length: 390 amino acids
Theoretical weight: 43.62 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q61743 (Residues: 1-390; Coverage: 100%)
Gene name: Kcnj11
Pfam:
InterPro:
ATP-sensitive inward rectifier potassium channel 11 in PDB entry 5ykf, assembly 1, front view.
ATP-sensitive inward rectifier potassium channel 11 in PDB entry 5ykf, assembly 1, side view.
ATP-sensitive inward rectifier potassium channel 11 in PDB entry 5ykf, assembly 1, top view.
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ATP-binding cassette sub-family C member 8 isoform X2
Chains: B, D, F, H
Length: 1582 amino acids
Theoretical weight: 177.3 KDa
Source organism: Mesocricetus auratus
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A1U7R319 (Residues: 1-1582; Coverage: 100%)
Gene name: Abcc8
Pfam:
InterPro:
ATP-binding cassette sub-family C member 8 isoform X2 in PDB entry 5ykf, assembly 1, front view.
ATP-binding cassette sub-family C member 8 isoform X2 in PDB entry 5ykf, assembly 1, side view.
ATP-binding cassette sub-family C member 8 isoform X2 in PDB entry 5ykf, assembly 1, top view.
Molecule details ›

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