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Crystal structure of SET7/9 in complex with a cyproheptadine derivative

X-ray diffraction
1.69Å resolution
PDB entry 5ylt coloured by chain, front view.
PDB entry 5ylt coloured by chain, side view.
PDB entry 5ylt coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Histone-lysine N-methyltransferase SETD7
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Multimeric state: monomeric
Accessible surface area: 12355.56 Å2
Buried surface area: 655.39 Å2
Dissociation area: 94.85 Å2
Dissociation energy (ΔGdiss): 0.39 kcal/mol
Dissociation entropy (TΔSdiss): 0.83 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-186700

Macromolecules

Histone-lysine N-methyltransferase SETD7
Chain: A
Length: 263 amino acids
Theoretical weight: 29.08 KDa
Source organism: Homo sapiens
Expression system: unidentified
UniProt:
  • Canonical: Q8WTS6 (Residues: 111-366; Coverage: 70%)
Gene names: KIAA1717, KMT7, SET7, SET9, SETD7
Pfam:
InterPro:
CATH:
Histone-lysine N-methyltransferase SETD7 in PDB entry 5ylt, assembly 1, front view.
Histone-lysine N-methyltransferase SETD7 in PDB entry 5ylt, assembly 1, side view.
Histone-lysine N-methyltransferase SETD7 in PDB entry 5ylt, assembly 1, top view.
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