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A T cell receptor in complex with HLA-A0201 restricted Hepatitis C virus NS3 peptide (KLVALGINAV)

X-ray diffraction
2.03Å resolution
PDB entry 5yxn coloured by chain, front view.
PDB entry 5yxn coloured by chain, side view.
PDB entry 5yxn coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 35945.83 Å2
Buried surface area: 11238.58 Å2
Dissociation area: 1,259.53 Å2
Dissociation energy (ΔGdiss): -1.36 kcal/mol
Dissociation entropy (TΔSdiss): 13.9 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-209022

Macromolecules

T cell receptor alpha chain
Chain: A
Length: 192 amino acids
Theoretical weight: 21.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
InterPro:
CATH: Immunoglobulins
T cell receptor alpha chain in PDB entry 5yxn, assembly 1, front view.
T cell receptor alpha chain in PDB entry 5yxn, assembly 1, side view.
T cell receptor alpha chain in PDB entry 5yxn, assembly 1, top view.
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T cell receptor beta chain
Chain: B
Length: 241 amino acids
Theoretical weight: 27.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
InterPro:
CATH: Immunoglobulins
T cell receptor beta chain in PDB entry 5yxn, assembly 1, front view.
T cell receptor beta chain in PDB entry 5yxn, assembly 1, side view.
T cell receptor beta chain in PDB entry 5yxn, assembly 1, top view.
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HLA class I histocompatibility antigen, A alpha chain
Chain: C
Length: 275 amino acids
Theoretical weight: 31.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Pfam:
InterPro:
CATH:
HLA class I histocompatibility antigen, A alpha chain in PDB entry 5yxn, assembly 1, front view.
HLA class I histocompatibility antigen, A alpha chain in PDB entry 5yxn, assembly 1, side view.
HLA class I histocompatibility antigen, A alpha chain in PDB entry 5yxn, assembly 1, top view.
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Beta-2-microglobulin
Chain: D
Length: 100 amino acids
Theoretical weight: 11.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 20-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
Beta-2-microglobulin in PDB entry 5yxn, assembly 1, front view.
Beta-2-microglobulin in PDB entry 5yxn, assembly 1, side view.
Beta-2-microglobulin in PDB entry 5yxn, assembly 1, top view.
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Serine protease/helicase NS3
Chain: I
Length: 10 amino acids
Theoretical weight: 998 Da
UniProt:
  • Canonical: P27958 (Residues: 1406-1415; Coverage: 0%)
Serine protease/helicase NS3 in PDB entry 5yxn, assembly 1, front view.
Serine protease/helicase NS3 in PDB entry 5yxn, assembly 1, side view.
Serine protease/helicase NS3 in PDB entry 5yxn, assembly 1, top view.
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