› › Function and Biology

Crystal structure of the DEAD domain of Human eIF4A with sanguinarine

Source organism: Homo sapiens
Biochemical function: ATP binding
Biological process: not assigned
Cellular component: not assigned

Quick links

EC 3.6.4.13: RNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (RNA helix unwinding)
Alternative Name(s):
  • CSFV NS3 helicase
  • DBP2
  • DDX17
  • DDX25
  • DDX3
  • DDX3X
  • DDX3Y
  • DDX4
  • DDX5
  • DEAD-box RNA helicase
  • DEAD-box protein DED1
  • DEAH-box RNA helicase
  • DEAH-box protein 2
  • DED1
  • DbpA
  • Dex(H/D) RNA helicase
  • EIF4A helicase
  • EhDEAD1
  • EhDEAD1 RNA helicase
  • GRTH/DDX25
  • KOKV helicase
  • Mtr4p
  • NPH-II
  • Nonstructural protein 3 helicase
  • RHA
  • RNA helicase A
  • RNA helicase DDX3
  • RNA helicase Hera
  • RNA-dependent ATPase
  • TGBp1 NTPase/helicase domain
  • VRH1

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00270
Domain description: DEAD/DEAH box helicase
Occurring in:
  1. Eukaryotic initiation factor 4A-I
The deposited structure of PDB entry 5zbz contains 1 copy of Pfam domain PF00270 (DEAD/DEAH box helicase) in Eukaryotic initiation factor 4A-I. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR014001
Domain description: Helicase superfamily 1/2, ATP-binding domain
Occurring in:
  1. Eukaryotic initiation factor 4A-I
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Eukaryotic initiation factor 4A-I
IPR000629
Domain description: ATP-dependent RNA helicase DEAD-box, conserved site
Occurring in:
  1. Eukaryotic initiation factor 4A-I
IPR011545
Domain description: DEAD/DEAH box helicase domain
Occurring in:
  1. Eukaryotic initiation factor 4A-I
IPR044728
Domain description: ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain
Occurring in:
  1. Eukaryotic initiation factor 4A-I
IPR014014
Domain description: RNA helicase, DEAD-box type, Q motif
Occurring in:
  1. Eukaryotic initiation factor 4A-I

Structure domain

CATH CATH domain
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Eukaryotic initiation factor 4A-I
The deposited structure of PDB entry 5zbz contains 1 copy of CATH domain 3.40.50.300 (Rossmann fold) in Eukaryotic initiation factor 4A-I. Showing 1 copy in chain A.

Quick links