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Crystal structure of the DEAD domain of Human eIF4A with sanguinarine

X-ray diffraction
1.309Å resolution
PDB entry 5zbz coloured by chain, front view.
PDB entry 5zbz coloured by chain, side view.
PDB entry 5zbz coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Eukaryotic initiation factor 4A-I
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Multimeric state: monomeric
Accessible surface area: 10616.41 Å2
Buried surface area: 272.05 Å2
Dissociation area: 136.02 Å2
Dissociation energy (ΔGdiss): -2.91 kcal/mol
Dissociation entropy (TΔSdiss): 1.28 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158100

Macromolecules

Eukaryotic initiation factor 4A-I
Chain: A
Length: 220 amino acids
Theoretical weight: 24.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P60842 (Residues: 20-238; Coverage: 54%)
Gene names: DDX2A, EIF4A, EIF4A1
Pfam: DEAD/DEAH box helicase
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
Eukaryotic initiation factor 4A-I in PDB entry 5zbz, assembly 1, front view.
Eukaryotic initiation factor 4A-I in PDB entry 5zbz, assembly 1, side view.
Eukaryotic initiation factor 4A-I in PDB entry 5zbz, assembly 1, top view.
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