› 6ke4

X-ray diffraction
2.3Å resolution

ABloop reengineered Ferritin Nanocage

Released:
DOI: 10.2210/pdb6ke4/pdb
PDB entry 6ke4 coloured by chain, front view.
PDB entry 6ke4 coloured by chain, side view.
PDB entry 6ke4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
AB loop engineered ferritin nanocages for drug loading under benign experimental conditions.
Wang W, Wang L, Li G, Zhao G, Zhao X, Wang H
Chem Commun (Camb) 55 12344-12347 (2019)
PMID: 31556881

Function and Biology Details

Reaction catalysed: 
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-526971 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ferritin heavy chain Chain: A
Molecule details ›
Chain: A
Length: 180 amino acids
Theoretical weight: 20.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02794 (Residues: 1-183; Coverage: 98%)
Gene names: FTH, FTH1, FTHL6, OK/SW-cl.84, PIG15
Sequence domains: Ferritin-like domain

Ligands and Environments

4 bound ligands:
Ligand FE 2 x FE
Ligand MG 3 x MG
Ligand CL 2 x CL
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: F432
Unit cell:
a: 182.642Å b: 182.642Å c: 182.642Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.19 0.236
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Ferritin Nanocage: A Versatile Nanocarrier Utilized in the Field of Food, Nutrition, and Medicine.
Zhang et al. (2020)
2 more