› 6nt3

Electron Microscopy
3.4Å resolution

Cryo-EM structure of a human-cockroach hybrid Nav channel.

Released:
DOI: 10.2210/pdb6nt3/pdb
PDB entry 6nt3 coloured by chain, front view.
PDB entry 6nt3 coloured by chain, side view.
PDB entry 6nt3 coloured by chain, top view.
Source organisms:
Primary publication:
Cryo-EM structures of a human-cockroach hybrid Nav channel in the presence and absence of the alpha-scorpion toxin AaH2.
Clairfeuille T, Rohou A, Payandeh J
Science (2019)
Related structures: EMD-0500

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-111947 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Sodium channel protein PaFPC1; Sodium channel protein type 9 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 1559 amino acids
Theoretical weight: 178.76 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: D0E0C2 (Residues: 1-269, 289-1155, 1287-1505; Coverage: 87%)
  • Canonical: Q15858 (Residues: 257-275, 1501-1631; Coverage: 8%)
Gene names: NENA, SCN9A
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
5 bound ligands:
Ligand NAG 4 x NAG
Ligand Y01 1 x Y01
Ligand 76F 4 x 76F
Ligand LHG 1 x LHG
Ligand AJP 1 x AJP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-0500
Expression system: Homo sapiens

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