› 6zox

Electron Microscopy
3Å resolution

Structure of Disulphide-stabilized SARS-CoV-2 Spike Protein Trimer (x2 disulphide-bond mutant, G413C, V987C, single Arg S1/S2 cleavage site)

Released:
DOI: 10.2210/pdb6zox/pdb
PDB entry 6zox coloured by chain, front view.
PDB entry 6zox coloured by chain, side view.
PDB entry 6zox coloured by chain, top view.
Source organism: Severe acute respiratory syndrome coronavirus 2
Primary publication:
A thermostable, closed SARS-CoV-2 spike protein trimer.
Xiong X, Qu K, Ciazynska KA, Hosmillo M, Carter AP, Ebrahimi S, Ke Z, Scheres SHW, Bergamaschi L, Grice GL, Zhang Y, Nathan JA, Baker S, James LC, Baxendale HE, Goodfellow I, Doffinger R, Briggs JAG
Nat Struct Mol Biol 27 934-941 (2020)
PMID: 32737467
Related structures: EMD-11329

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144650 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1247 amino acids
Theoretical weight: 138.36 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 14-1211; Coverage: 95%)
Gene names: 2, S
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 33 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3Å
Relevant EMDB volumes: EMD-11329
Expression system: Homo sapiens

Quick links

Citations

27 review citations

Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy.
Zhang et al. (2021)
26 more

11 mentions without citation

An Overview of the Crystallized Structures of the SARS-CoV-2.
Ionescu MI. (2020)
10 more