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Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana and Dc1a

Electron Microscopy
2.8Å resolution
PDB entry 6a90 coloured by chain, front view.
PDB entry 6a90 coloured by chain, side view.
PDB entry 6a90 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Beta-diguetoxin-Dc1a and Sodium channel protein PaFPC1
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Multimeric state: hetero dimer
Accessible surface area: 71709.57 Å2
Buried surface area: 4164.75 Å2
Dissociation area: 1,223.54 Å2
Dissociation energy (ΔGdiss): 0.75 kcal/mol
Dissociation entropy (TΔSdiss): 11.25 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-111950

Macromolecules

Sodium channel protein PaFPC1
Chain: A
Length: 1596 amino acids
Theoretical weight: 183.88 KDa
Source organism: Periplaneta americana
Expression system: Homo sapiens
UniProt:
  • Canonical: D0E0C2 (Residues: 1-1553; Coverage: 100%)
Pfam:
InterPro:
Sodium channel protein PaFPC1 in PDB entry 6a90, assembly 1, front view.
Sodium channel protein PaFPC1 in PDB entry 6a90, assembly 1, side view.
Sodium channel protein PaFPC1 in PDB entry 6a90, assembly 1, top view.
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Beta-diguetoxin-Dc1a
Chain: B
Length: 57 amino acids
Theoretical weight: 6.5 KDa
Source organism: Diguetia canities
Expression system: Escherichia coli
UniProt:
  • Canonical: P49126 (Residues: 39-94; Coverage: 73%)
Pfam: Spider Toxins mu-diguetoxin-1 a, b and c
InterPro: Beta/Mu-diguetoxin-1
CATH: Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4
Beta-diguetoxin-Dc1a in PDB entry 6a90, assembly 1, front view.
Beta-diguetoxin-Dc1a in PDB entry 6a90, assembly 1, side view.
Beta-diguetoxin-Dc1a in PDB entry 6a90, assembly 1, top view.
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