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Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with SQ109

Source organisms:
Biochemical function: hydrolase activity, acting on glycosyl bonds
Biological process: viral release from host cell by cytolysis
Cellular component: host cell cytoplasm

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EC 3.2.1.17: Lysozyme

Reaction catalysed:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Systematic name:
Peptidoglycan N-acetylmuramoylhydrolase
Alternative Name(s):
  • 1,4-N-acetylmuramidase
  • Globulin G
  • Globulin G1
  • L-7001
  • Lysozyme g
  • Mucopeptide N-acetylmuramoylhydrolase
  • Mucopeptide glucohydrolase
  • Muramidase
  • N,O-diacetylmuramidase
  • PR1-lysozyme

GO terms

Sequence families

Pfam Protein families (Pfam)
PF03176
Domain description: MMPL family
Occurring in:
  1. Endolysin; Trehalose monomycolate exporter MmpL3
The deposited structure of PDB entry 6ajg contains 2 copies of Pfam domain PF03176 (MMPL family) in Endolysin. Showing 2 copies in chain A.

PF00959
Domain description: Phage lysozyme
Occurring in:
  1. Endolysin; Trehalose monomycolate exporter MmpL3
The deposited structure of PDB entry 6ajg contains 1 copy of Pfam domain PF00959 (Phage lysozyme) in Endolysin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001165
Domain description: T4-type lysozyme
Occurring in:
  1. Endolysin; Trehalose monomycolate exporter MmpL3
IPR004869
Domain description: Membrane transport protein MMPL domain
Occurring in:
  1. Endolysin; Trehalose monomycolate exporter MmpL3
IPR002196
Domain description: Glycoside hydrolase, family 24
Occurring in:
  1. Endolysin; Trehalose monomycolate exporter MmpL3
IPR023346
Domain description: Lysozyme-like domain superfamily
Occurring in:
  1. Endolysin; Trehalose monomycolate exporter MmpL3
IPR023347
Domain description: Lysozyme domain superfamily
Occurring in:
  1. Endolysin; Trehalose monomycolate exporter MmpL3
IPR034690
Domain description: Endolysin T4 type
Occurring in:
  1. Endolysin; Trehalose monomycolate exporter MmpL3

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