› 6aze

X-ray diffraction
2.45Å resolution

Crystal Structure of the BPTF PHD-bromodomain module bound to H3KC4me3 methyl lysine analog

Released:
DOI: 10.2210/pdb6aze/pdb
PDB entry 6aze coloured by chain, front view.
PDB entry 6aze coloured by chain, side view.
PDB entry 6aze coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Chen Z, Ruthenburg AJ

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159403 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nucleosome-remodeling factor subunit BPTF Chain: A
Molecule details ›
Chain: A
Length: 167 amino acids
Theoretical weight: 19.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12830 (Residues: 2866-3032; Coverage: 6%)
Gene names: BPTF, FAC1, FALZ
Sequence domains:
Structure domains:
Histone H3.1 Chain: P
Molecule details ›
Chain: P
Length: 6 amino acids
Theoretical weight: 766 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P68431 (Residues: 2-7; Coverage: 4%)
Gene names: H3C1, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3FA, H3FB, H3FC HIST1H3C, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
1 modified residue:
Ligand ML3 1 x ML3

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P212121
Unit cell:
a: 38.263Å b: 64.13Å c: 85.67Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.18 0.213
Expression systems:
  • Escherichia coli
  • Not provided

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