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Crystal Structure of the BPTF PHD-bromodomain module bound to H3KC4me3 methyl lysine analog

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: regulation of transcription by RNA polymerase II
Cellular component: NURF complex

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GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00439
Domain description: Bromodomain
Occurring in:
  1. Nucleosome-remodeling factor subunit BPTF
The deposited structure of PDB entry 6aze contains 1 copy of Pfam domain PF00439 (Bromodomain) in Nucleosome-remodeling factor subunit BPTF. Showing 1 copy in chain A.

PF00628
Domain description: PHD-finger
Occurring in:
  1. Nucleosome-remodeling factor subunit BPTF
The deposited structure of PDB entry 6aze contains 1 copy of Pfam domain PF00628 (PHD-finger) in Nucleosome-remodeling factor subunit BPTF. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001487
Domain description: Bromodomain
Occurring in:
  1. Nucleosome-remodeling factor subunit BPTF
IPR036427
Domain description: Bromodomain-like superfamily
Occurring in:
  1. Nucleosome-remodeling factor subunit BPTF
IPR019787
Domain description: Zinc finger, PHD-finger
Occurring in:
  1. Nucleosome-remodeling factor subunit BPTF
IPR018359
Domain description: Bromodomain, conserved site
Occurring in:
  1. Nucleosome-remodeling factor subunit BPTF
IPR019786
Domain description: Zinc finger, PHD-type, conserved site
Occurring in:
  1. Nucleosome-remodeling factor subunit BPTF
IPR001965
Domain description: Zinc finger, PHD-type
Occurring in:
  1. Nucleosome-remodeling factor subunit BPTF
IPR011011
Domain description: Zinc finger, FYVE/PHD-type
Occurring in:
  1. Nucleosome-remodeling factor subunit BPTF
IPR038028
Domain description: Nucleosome-remodeling factor subunit BPTF
Occurring in:
  1. Nucleosome-remodeling factor subunit BPTF
IPR013083
Domain description: Zinc finger, RING/FYVE/PHD-type
Occurring in:
  1. Nucleosome-remodeling factor subunit BPTF

Structure domains

CATH CATH domains
1.20.920.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Histone Acetyltransferase; Chain A
Homology: Bromodomain-like
Occurring in:
  1. Nucleosome-remodeling factor subunit BPTF
The deposited structure of PDB entry 6aze contains 1 copy of CATH domain 1.20.920.10 (Histone Acetyltransferase; Chain A) in Nucleosome-remodeling factor subunit BPTF. Showing 1 copy in chain A.
3.30.40.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Herpes Virus-1
Homology: Zinc/RING finger domain, C3HC4 (zinc finger)
Occurring in:
  1. Nucleosome-remodeling factor subunit BPTF
The deposited structure of PDB entry 6aze contains 1 copy of CATH domain 3.30.40.10 (Herpes Virus-1) in Nucleosome-remodeling factor subunit BPTF. Showing 1 copy in chain A.

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