Function and Biology

Mechanisms of Opening and Closing of the Bacterial Replicative Helicase: The DnaB Helicase and Lambda P Helicase Loader Complex

Source organisms:
Biochemical function: 5'-3' DNA helicase activity
Biological process: DNA replication initiation
Cellular component: DnaB-DnaC-Rep-PriC complex

Sequence families

Pfam Protein families (Pfam)
PF03796
Domain description: DnaB-like helicase C terminal domain
Occurring in:
  1. Replicative DNA helicase DnaB
The deposited structure of PDB entry 6bbm contains 6 copies of Pfam domain PF03796 (DnaB-like helicase C terminal domain) in Replicative DNA helicase. Showing 1 copy in chain D.

PF00772
Domain description: DnaB-like helicase N terminal domain
Occurring in:
  1. Replicative DNA helicase DnaB
The deposited structure of PDB entry 6bbm contains 6 copies of Pfam domain PF00772 (DnaB-like helicase N terminal domain) in Replicative DNA helicase. Showing 1 copy in chain D.

PF06992
Domain description: Replication protein P
Occurring in:
  1. Helicase loader
The deposited structure of PDB entry 6bbm contains 5 copies of Pfam domain PF06992 (Replication protein P) in Replication protein P. Showing 1 copy in chain G [auth V] (this domain is out of the observed residue ranges!).

InterPro InterPro annotations
IPR007694
Domain description: DNA helicase, DnaB-like, C-terminal
Occurring in:
  1. Replicative DNA helicase DnaB
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Replicative DNA helicase DnaB
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. Replicative DNA helicase DnaB
IPR007693
Domain description: DNA helicase, DnaB-like, N-terminal
Occurring in:
  1. Replicative DNA helicase DnaB
IPR007692
Domain description: DNA helicase, DnaB type
Occurring in:
  1. Replicative DNA helicase DnaB
IPR036185
Domain description: DNA helicase, DnaB-like, N-terminal domain superfamily
Occurring in:
  1. Replicative DNA helicase DnaB
IPR016136
Domain description: DNA helicase DnaB, N-terminal/DNA primase DnaG, C-terminal
Occurring in:
  1. Replicative DNA helicase DnaB
IPR009731
Domain description: Replication P-like
Occurring in:
  1. Helicase loader