› 6bdl

X-ray diffraction
1.96Å resolution

Crystal structure of cGMP-dependent protein kinase Ialpha (PKG Ialpha) catalytic domain in apo state

Released:
DOI: 10.2210/pdb6bdl/pdb
PDB entry 6bdl coloured by chain, front view.
PDB entry 6bdl coloured by chain, side view.
PDB entry 6bdl coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Qin L, Sankaran B, Kim C

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171844 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
cGMP-dependent protein kinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 347 amino acids
Theoretical weight: 39.47 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q13976 (Residues: 327-671; Coverage: 51%)
Gene names: PRKG1, PRKG1B, PRKGR1A, PRKGR1B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand IMD 2 x IMD
1 modified residue:
Ligand TPO 2 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P2
Unit cell:
a: 85.114Å b: 50.879Å c: 85.531Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.209 0.222
Expression system: Trichoplusia ni

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