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Crystal structure of cGMP-dependent protein kinase Ialpha (PKG Ialpha) catalytic domain in apo state

X-ray diffraction
1.96Å resolution
PDB entry 6bdl coloured by chain, front view.
PDB entry 6bdl coloured by chain, side view.
PDB entry 6bdl coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: cGMP-dependent protein kinase 1
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Multimeric state: monomeric
Accessible surface area: 15367.49 Å2
Buried surface area: 258.02 Å2
Dissociation area: 129.01 Å2
Dissociation energy (ΔGdiss): -3.35 kcal/mol
Dissociation entropy (TΔSdiss): -0.15 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171844
Assembly 2
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Assembly Name: cGMP-dependent protein kinase 1
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Multimeric state: monomeric
Accessible surface area: 15426.16 Å2
Buried surface area: 261.26 Å2
Dissociation area: 130.63 Å2
Dissociation energy (ΔGdiss): -3.5 kcal/mol
Dissociation entropy (TΔSdiss): -0.15 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171844

Macromolecules

cGMP-dependent protein kinase 1
Chains: A, B
Length: 347 amino acids
Theoretical weight: 39.47 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q13976 (Residues: 327-671; Coverage: 51%)
Gene names: PRKG1, PRKG1B, PRKGR1A, PRKGR1B
Pfam: Protein kinase domain
InterPro:
CATH:
cGMP-dependent protein kinase 1 in PDB entry 6bdl, assembly 1, front view.
cGMP-dependent protein kinase 1 in PDB entry 6bdl, assembly 1, side view.
cGMP-dependent protein kinase 1 in PDB entry 6bdl, assembly 1, top view.
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