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Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain

Electron Microscopy
7.2Å resolution
PDB entry 6bf9 coloured by chain, front view.
PDB entry 6bf9 coloured by chain, side view.
PDB entry 6bf9 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero hexamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 125951.78 Å2
Buried surface area: 13951.48 Å2
Dissociation area: 3,217.1 Å2
Dissociation energy (ΔGdiss): -10.37 kcal/mol
Dissociation entropy (TΔSdiss): 46.11 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-143691

Macromolecules

Insulin-degrading enzyme
Chains: A, B
Length: 966 amino acids
Theoretical weight: 111.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P14735 (Residues: 46-1011; Coverage: 95%)
Gene name: IDE
Pfam:
InterPro:
Insulin-degrading enzyme in PDB entry 6bf9, assembly 1, front view.
Insulin-degrading enzyme in PDB entry 6bf9, assembly 1, side view.
Insulin-degrading enzyme in PDB entry 6bf9, assembly 1, top view.
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Immunoglobulin gamma-1 heavy chain
Chains: C, E
Length: 218 amino acids
Theoretical weight: 23.06 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P0DOX5 (Residues: 1-49, 50-219; Coverage: 48%)
Pfam:
InterPro:
Immunoglobulin gamma-1 heavy chain in PDB entry 6bf9, assembly 1, front view.
Immunoglobulin gamma-1 heavy chain in PDB entry 6bf9, assembly 1, side view.
Immunoglobulin gamma-1 heavy chain in PDB entry 6bf9, assembly 1, top view.
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Immunoglobulin kappa light chain
Chains: D, F
Length: 211 amino acids
Theoretical weight: 23.09 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P0DOX7 (Residues: 1-211; Coverage: 99%)
Pfam:
InterPro:
Immunoglobulin kappa light chain in PDB entry 6bf9, assembly 1, front view.
Immunoglobulin kappa light chain in PDB entry 6bf9, assembly 1, side view.
Immunoglobulin kappa light chain in PDB entry 6bf9, assembly 1, top view.
Molecule details ›

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