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Caspase-3 Mutant - D9A,D28A,S150D

X-ray diffraction
2.125Å resolution
PDB entry 6bg0 coloured by chain, front view.
PDB entry 6bg0 coloured by chain, side view.
PDB entry 6bg0 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Caspase-3 and peptide
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Multimeric state: hetero trimer
Accessible surface area: 10910.93 Å2
Buried surface area: 6012.61 Å2
Dissociation area: 662.95 Å2
Dissociation energy (ΔGdiss): 3.28 kcal/mol
Dissociation entropy (TΔSdiss): 5.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154698
Assembly 2 (preferred)
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Assembly Name: Caspase-3 and peptide
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Multimeric state: hetero trimer
Accessible surface area: 10643.69 Å2
Buried surface area: 5896.79 Å2
Dissociation area: 604.42 Å2
Dissociation energy (ΔGdiss): 2.76 kcal/mol
Dissociation entropy (TΔSdiss): 5.59 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154698

Macromolecules

Caspase-3 subunit p17
Chains: A, B
Length: 175 amino acids
Theoretical weight: 19.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P42574 (Residues: 1-175; Coverage: 63%)
Gene names: CASP3, CPP32
Pfam: Caspase domain
InterPro:
CATH: Rossmann fold
Caspase-3 subunit p17 in PDB entry 6bg0, assembly 2, front view.
Caspase-3 subunit p17 in PDB entry 6bg0, assembly 2, side view.
Caspase-3 subunit p17 in PDB entry 6bg0, assembly 2, top view.
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Caspase-3 subunit p12
Chains: C, D
Length: 102 amino acids
Theoretical weight: 11.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P42574 (Residues: 176-277; Coverage: 37%)
Gene names: CASP3, CPP32
Pfam: Caspase domain
InterPro:
CATH: Caspase-like
Caspase-3 subunit p12 in PDB entry 6bg0, assembly 2, front view.
Caspase-3 subunit p12 in PDB entry 6bg0, assembly 2, side view.
Caspase-3 subunit p12 in PDB entry 6bg0, assembly 2, top view.
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AC-ASP-GLU-VAL-ASP-CMK
Chains: F, G
Length: 6 amino acids
Theoretical weight: 535 Da
Source organism: Homo sapiens
Expression system: Not provided
AC-ASP-GLU-VAL-ASP-CMK in PDB entry 6bg0, assembly 2, front view.
AC-ASP-GLU-VAL-ASP-CMK in PDB entry 6bg0, assembly 2, side view.
AC-ASP-GLU-VAL-ASP-CMK in PDB entry 6bg0, assembly 2, top view.
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