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Crystal structure of the PI3KC2alpha PX domain in space group P432

X-ray diffraction
2.604Å resolution
PDB entry 6bub coloured by chain, front view.
PDB entry 6bub coloured by chain, side view.
PDB entry 6bub coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
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Multimeric state: monomeric
Accessible surface area: 7487.56 Å2
Buried surface area: 366.73 Å2
Dissociation area: 91.19 Å2
Dissociation energy (ΔGdiss): 0.39 kcal/mol
Dissociation entropy (TΔSdiss): 0.83 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126279

Macromolecules

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
Chain: A
Length: 143 amino acids
Theoretical weight: 16.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O00443 (Residues: 1405-1544; Coverage: 8%)
Gene name: PIK3C2A
Pfam: PX domain
InterPro:
CATH: Phox-like domain
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha in PDB entry 6bub, assembly 1, front view.
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha in PDB entry 6bub, assembly 1, side view.
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha in PDB entry 6bub, assembly 1, top view.
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