6c3o

Electron Microscopy
3.9Å resolution

Cryo-EM structure of human KATP bound to ATP and ADP in quatrefoil form

Released:
Source organism: Homo sapiens
Related structures: EMD-7338

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-555280 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ATP-sensitive inward rectifier potassium channel 11 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 406 amino acids
Theoretical weight: 45.14 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q14654 (Residues: 1-390; Coverage: 100%)
  • Best match: Q14654-2 (Residues: 1-303)
Gene name: KCNJ11
Sequence domains:
Structure domains:
ATP-binding cassette sub-family C member 8 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 1581 amino acids
Theoretical weight: 177.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q09428 (Residues: 1-1581; Coverage: 100%)
  • Best match: Q09428-2 (Residues: 1-1582)
Gene names: ABCC8, HRINS, SUR, SUR1
Sequence domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-7338
Expression system: Homo sapiens