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Cryo-EM structure of human KATP bound to ATP and ADP in quatrefoil form

Source organism: Homo sapiens
Biochemical function: transmembrane transporter binding
Biological process: potassium ion import across plasma membrane
Cellular component: presynaptic membrane

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00005
Domain description: ABC transporter
Occurring in:
  1. ATP-binding cassette sub-family C member 8
The deposited structure of PDB entry 6c3o contains 8 copies of Pfam domain PF00005 (ABC transporter) in ATP-binding cassette sub-family C member 8. Showing 2 copies in chain E.

PF00664
Domain description: ABC transporter transmembrane region
Occurring in:
  1. ATP-binding cassette sub-family C member 8
The deposited structure of PDB entry 6c3o contains 8 copies of Pfam domain PF00664 (ABC transporter transmembrane region) in ATP-binding cassette sub-family C member 8. Showing 2 copies in chain E.

PF17655
Domain description: Inward rectifier potassium channel C-terminal domain
Occurring in:
  1. ATP-sensitive inward rectifier potassium channel 11
The deposited structure of PDB entry 6c3o contains 4 copies of Pfam domain PF17655 (Inward rectifier potassium channel C-terminal domain) in ATP-sensitive inward rectifier potassium channel 11. Showing 1 copy in chain A.

PF01007
Domain description: Inward rectifier potassium channel transmembrane domain
Occurring in:
  1. ATP-sensitive inward rectifier potassium channel 11
The deposited structure of PDB entry 6c3o contains 4 copies of Pfam domain PF01007 (Inward rectifier potassium channel transmembrane domain) in ATP-sensitive inward rectifier potassium channel 11. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR016449
Domain description: Potassium channel, inwardly rectifying, Kir
Occurring in:
  1. ATP-sensitive inward rectifier potassium channel 11
IPR003279
Domain description: Potassium channel, inwardly rectifying, Kir6.2
Occurring in:
  1. ATP-sensitive inward rectifier potassium channel 11
IPR000388
Domain description: ATP-binding cassette sub-family C member 8/9
Occurring in:
  1. ATP-binding cassette sub-family C member 8
IPR000844
Domain description: ATP-binding cassette subfamily C member 8
Occurring in:
  1. ATP-binding cassette sub-family C member 8
IPR003439
Domain description: ABC transporter-like, ATP-binding domain
Occurring in:
  1. ATP-binding cassette sub-family C member 8
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. ATP-binding cassette sub-family C member 8
IPR011527
Domain description: ABC transporter type 1, transmembrane domain
Occurring in:
  1. ATP-binding cassette sub-family C member 8
IPR036640
Domain description: ABC transporter type 1, transmembrane domain superfamily
Occurring in:
  1. ATP-binding cassette sub-family C member 8
IPR017871
Domain description: ABC transporter-like, conserved site
Occurring in:
  1. ATP-binding cassette sub-family C member 8
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. ATP-binding cassette sub-family C member 8
IPR041647
Domain description: Inward rectifier potassium channel, C-terminal
Occurring in:
  1. ATP-sensitive inward rectifier potassium channel 11
IPR014756
Domain description: Immunoglobulin E-set
Occurring in:
  1. ATP-sensitive inward rectifier potassium channel 11
IPR040445
Domain description: Potassium channel, inwardly rectifying, transmembrane domain
Occurring in:
  1. ATP-sensitive inward rectifier potassium channel 11
IPR013518
Domain description: Potassium channel, inwardly rectifying, Kir, cytoplasmic
Occurring in:
  1. ATP-sensitive inward rectifier potassium channel 11

Structure domains

CATH CATH domains
2.60.40.1400
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: G protein-activated inward rectifier potassium channel 1
Occurring in:
  1. ATP-sensitive inward rectifier potassium channel 11
The deposited structure of PDB entry 6c3o contains 4 copies of CATH domain 2.60.40.1400 (Immunoglobulin-like) in ATP-sensitive inward rectifier potassium channel 11. Showing 1 copy in chain A.
1.10.287.70
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helix Hairpins
Homology: Helix Hairpins
Occurring in:
  1. ATP-sensitive inward rectifier potassium channel 11
The deposited structure of PDB entry 6c3o contains 4 copies of CATH domain 1.10.287.70 (Helix Hairpins) in ATP-sensitive inward rectifier potassium channel 11. Showing 1 copy in chain A.

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