› › Function and Biology

Crystal structure of fragment 3-(quinolin-2-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain

Source organism: Homo sapiens
Biochemical function: zinc ion binding
Biological process: not assigned
Cellular component: not assigned

Quick links

EC 3.5.1.98: Histone deacetylase

Reaction catalysed:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone
Systematic name:
Histone amidohydrolase
Alternative Name(s):
  • HDAC

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF02148
Domain description: Zn-finger in ubiquitin-hydrolases and other protein
Occurring in:
  1. Histone deacetylase 6
The deposited structure of PDB entry 6cea contains 1 copy of Pfam domain PF02148 (Zn-finger in ubiquitin-hydrolases and other protein) in Histone deacetylase 6. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001607
Domain description: Zinc finger, UBP-type
Occurring in:
  1. Histone deacetylase 6
IPR013083
Domain description: Zinc finger, RING/FYVE/PHD-type
Occurring in:
  1. Histone deacetylase 6

Structure domain

CATH CATH domain
3.30.40.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Herpes Virus-1
Homology: Zinc/RING finger domain, C3HC4 (zinc finger)
Occurring in:
  1. Histone deacetylase 6
The deposited structure of PDB entry 6cea contains 1 copy of CATH domain 3.30.40.10 (Herpes Virus-1) in Histone deacetylase 6. Showing 1 copy in chain A.

Quick links