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Crystal structure of fragment 3-(quinolin-2-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain

X-ray diffraction
1.6Å resolution
PDB entry 6cea coloured by chain, front view.
PDB entry 6cea coloured by chain, side view.
PDB entry 6cea coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Histone deacetylase 6
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Multimeric state: monomeric
Accessible surface area: 5650.3 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-193657

Macromolecules

Histone deacetylase 6
Chain: A
Length: 107 amino acids
Theoretical weight: 11.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UBN7 (Residues: 1109-1213; Coverage: 9%)
Gene names: HDAC6, JM21, KIAA0901
Pfam: Zn-finger in ubiquitin-hydrolases and other protein
InterPro:
CATH: Zinc/RING finger domain, C3HC4 (zinc finger)
Histone deacetylase 6 in PDB entry 6cea, assembly 1, front view.
Histone deacetylase 6 in PDB entry 6cea, assembly 1, side view.
Histone deacetylase 6 in PDB entry 6cea, assembly 1, top view.
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