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Cryo-EM structure of the human SK4/calmodulin channel complex in the Ca2+ bound state II

Electron Microscopy
4.7Å resolution
PDB entry 6cno coloured by chain, front view.
PDB entry 6cno coloured by chain, side view.
PDB entry 6cno coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero octamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Calmodulin-1 and Intermediate conductance calcium-activated potassium channel protein 4
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Multimeric state: hetero octamer
Accessible surface area: 105708.59 Å2
Buried surface area: 32288.21 Å2
Dissociation area: 8,867.59 Å2
Dissociation energy (ΔGdiss): 107.04 kcal/mol
Dissociation entropy (TΔSdiss): 53.94 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-127535

Macromolecules

Intermediate conductance calcium-activated potassium channel protein 4
Chains: A, B, C, D
Length: 427 amino acids
Theoretical weight: 47.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O15554 (Residues: 1-427; Coverage: 100%)
Gene names: IK1, IKCA1, KCA4, KCNN4, SK4
Pfam:
InterPro:
Intermediate conductance calcium-activated potassium channel protein 4 in PDB entry 6cno, assembly 1, front view.
Intermediate conductance calcium-activated potassium channel protein 4 in PDB entry 6cno, assembly 1, side view.
Intermediate conductance calcium-activated potassium channel protein 4 in PDB entry 6cno, assembly 1, top view.
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Calmodulin-1
Chains: E, F, G, H
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DP23 (Residues: 1-149; Coverage: 100%)
Gene names: CALM, CALM1, CAM, CAM1
Pfam: EF-hand domain pair
InterPro:
Calmodulin-1 in PDB entry 6cno, assembly 1, front view.
Calmodulin-1 in PDB entry 6cno, assembly 1, side view.
Calmodulin-1 in PDB entry 6cno, assembly 1, top view.
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