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Crystal structure of Tyrosine-protein kinase receptor

X-ray diffraction
2.46Å resolution
PDB entry 6d22 coloured by chain, front view.
PDB entry 6d22 coloured by chain, side view.
PDB entry 6d22 coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: High affinity nerve growth factor receptor
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Multimeric state: monomeric
Accessible surface area: 15302.44 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138088
Assembly 2
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Assembly Name: High affinity nerve growth factor receptor
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Multimeric state: homo dimer
Accessible surface area: 28512.13 Å2
Buried surface area: 2078.13 Å2
Dissociation area: 1,039.07 Å2
Dissociation energy (ΔGdiss): 1.51 kcal/mol
Dissociation entropy (TΔSdiss): 13.56 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138092

Macromolecules

High affinity nerve growth factor receptor
Chain: A
Length: 307 amino acids
Theoretical weight: 34.97 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P04629 (Residues: 502-796; Coverage: 39%)
Gene names: MTC, NTRK1, TRK, TRKA
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
High affinity nerve growth factor receptor in PDB entry 6d22, assembly 1, front view.
High affinity nerve growth factor receptor in PDB entry 6d22, assembly 1, side view.
High affinity nerve growth factor receptor in PDB entry 6d22, assembly 1, top view.
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