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HLA-B*57:01 presenting GSFDYSGVHLW

X-ray diffraction
1.83Å resolution
PDB entry 6d2r coloured by chain, front view.
PDB entry 6d2r coloured by chain, side view.
PDB entry 6d2r coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Major Histocompatibility Complex
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Multimeric state: hetero trimer
Accessible surface area: 19309.39 Å2
Buried surface area: 4330.24 Å2
Dissociation area: 841.05 Å2
Dissociation energy (ΔGdiss): 4.73 kcal/mol
Dissociation entropy (TΔSdiss): 7.83 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135228

Macromolecules

HLA class I histocompatibility antigen, B alpha chain
Chain: A
Length: 276 amino acids
Theoretical weight: 31.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P01889 (Residues: 25-300; Coverage: 82%)
Gene names: HLA-B, HLAB
Pfam:
InterPro:
CATH:
HLA class I histocompatibility antigen, B alpha chain in PDB entry 6d2r, assembly 1, front view.
HLA class I histocompatibility antigen, B alpha chain in PDB entry 6d2r, assembly 1, side view.
HLA class I histocompatibility antigen, B alpha chain in PDB entry 6d2r, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P01889  
127620406080100120140160180200220240260
 
100200
UniProt
P01889
Chains
Domains
Secondary structure
Flexibility predictions
Interaction interfaces
Sequence conservation
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Beta-2-microglobulin
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
Beta-2-microglobulin in PDB entry 6d2r, assembly 1, front view.
Beta-2-microglobulin in PDB entry 6d2r, assembly 1, side view.
Beta-2-microglobulin in PDB entry 6d2r, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P61769  
1100102030405060708090100
 
50100MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM
UniProt
P61769
Chains
Domains
Secondary structure
Flexibility predictions
Interaction interfaces
Sequence conservation
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GLY-SER-PHE-ASP-TYR-SER-GLY-VAL-HIS-LEU-TRP
Chain: C
Length: 11 amino acids
Theoretical weight: 1.27 KDa
Source organism: synthetic construct
Expression system: Not provided
GLY-SER-PHE-ASP-TYR-SER-GLY-VAL-HIS-LEU-TRP in PDB entry 6d2r, assembly 1, front view.
GLY-SER-PHE-ASP-TYR-SER-GLY-VAL-HIS-LEU-TRP in PDB entry 6d2r, assembly 1, side view.
GLY-SER-PHE-ASP-TYR-SER-GLY-VAL-HIS-LEU-TRP in PDB entry 6d2r, assembly 1, top view.
1111234567891011
 
510GSFDYSGVHLW
Chains
RSRZ Outlier Chain C (auth C)
Chain C (auth C)
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Sequence conservation
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