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Crystal structure of human anti-tau antibody CBTAU-27.1

X-ray diffraction
1.9Å resolution
PDB entry 6dcv coloured by chain, front view.
PDB entry 6dcv coloured by chain, side view.
PDB entry 6dcv coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero dimer
Accessible surface area: 19973.26 Å2
Buried surface area: 4480.06 Å2
Dissociation area: 2,104.57 Å2
Dissociation energy (ΔGdiss): 23.46 kcal/mol
Dissociation entropy (TΔSdiss): 13.28 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134615
Assembly 2 (preferred)
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Assembly Name: IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero dimer
Accessible surface area: 19791.57 Å2
Buried surface area: 4390.99 Å2
Dissociation area: 2,098.29 Å2
Dissociation energy (ΔGdiss): 24.06 kcal/mol
Dissociation entropy (TΔSdiss): 13.27 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134615

Macromolecules

Immunoglobulin kappa constant
Chains: A, L
Length: 220 amino acids
Theoretical weight: 24.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01834 (Residues: 1-107; Coverage: 100%)
Gene name: IGKC
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
Immunoglobulin kappa constant in PDB entry 6dcv, assembly 2, front view.
Immunoglobulin kappa constant in PDB entry 6dcv, assembly 2, side view.
Immunoglobulin kappa constant in PDB entry 6dcv, assembly 2, top view.
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Immunoglobulin heavy constant gamma 1
Chains: B, H
Length: 231 amino acids
Theoretical weight: 24.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 1-107; Coverage: 27%)
Gene name: IGHG1
Pfam: Immunoglobulin C1-set domain
InterPro:
Immunoglobulin heavy constant gamma 1 in PDB entry 6dcv, assembly 2, front view.
Immunoglobulin heavy constant gamma 1 in PDB entry 6dcv, assembly 2, side view.
Immunoglobulin heavy constant gamma 1 in PDB entry 6dcv, assembly 2, top view.
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