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SPRY domain-containing SOCS box protein 2 complexed with WDINNN(BAL) cyclic peptide inhibitor

X-ray diffraction
2.4Å resolution
PDB entry 6dn5 coloured by chain, front view.
PDB entry 6dn5 coloured by chain, side view.
PDB entry 6dn5 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: SPRY domain-containing SOCS box protein 2 and peptide
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Multimeric state: hetero dimer
Accessible surface area: 9447.34 Å2
Buried surface area: 974.7 Å2
Dissociation area: 316.59 Å2
Dissociation energy (ΔGdiss): -3.28 kcal/mol
Dissociation entropy (TΔSdiss): 6.29 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-166609

Macromolecules

SPRY domain-containing SOCS box protein 2
Chain: A
Length: 217 amino acids
Theoretical weight: 23.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q99619 (Residues: 26-219; Coverage: 74%)
Gene names: GRCC9, SPSB2, SSB2
Pfam: SPRY domain
InterPro:
SPRY domain-containing SOCS box protein 2 in PDB entry 6dn5, assembly 1, front view.
SPRY domain-containing SOCS box protein 2 in PDB entry 6dn5, assembly 1, side view.
SPRY domain-containing SOCS box protein 2 in PDB entry 6dn5, assembly 1, top view.
Molecule details ›

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WDINNN(BAL) cyclic peptide inhibitor
Chain: B
Length: 7 amino acids
Theoretical weight: 846 Da
Source organism: Homo sapiens
Expression system: Not provided
WDINNN(BAL) cyclic peptide inhibitor in PDB entry 6dn5, assembly 1, front view.
WDINNN(BAL) cyclic peptide inhibitor in PDB entry 6dn5, assembly 1, side view.
WDINNN(BAL) cyclic peptide inhibitor in PDB entry 6dn5, assembly 1, top view.
Molecule details ›

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