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Crystal structure of dihydrofolate reductase from Staphylococcus aureus MW2 bound to NADP and p218

X-ray diffraction
1.9Å resolution
PDB entry 6e4e coloured by chain, front view.
PDB entry 6e4e coloured by chain, side view.
PDB entry 6e4e coloured by chain, top view.
Source organism: Staphylococcus aureus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Dihydrofolate reductase
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Multimeric state: monomeric
Accessible surface area: 7912.48 Å2
Buried surface area: 1204.12 Å2
Dissociation area: 602.06 Å2
Dissociation energy (ΔGdiss): 8.23 kcal/mol
Dissociation entropy (TΔSdiss): 6.5 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140887

Macromolecules

Dihydrofolate reductase
Chain: A
Length: 182 amino acids
Theoretical weight: 20.74 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A017 (Residues: 1-159; Coverage: 100%)
Gene name: folA
Pfam: Dihydrofolate reductase
InterPro:
CATH: Dihydrofolate Reductase, subunit A
Dihydrofolate reductase in PDB entry 6e4e, assembly 1, front view.
Dihydrofolate reductase in PDB entry 6e4e, assembly 1, side view.
Dihydrofolate reductase in PDB entry 6e4e, assembly 1, top view.
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