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cryo-EM structure of human TRPML1 with ML-SA1 and PI35P2

Electron Microscopy
3.73Å resolution
PDB entry 6e7z coloured by chain, front view.
PDB entry 6e7z coloured by chain, side view.
PDB entry 6e7z coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mucolipin-1
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Multimeric state: homo tetramer
Accessible surface area: 97568.66 Å2
Buried surface area: 28519.2 Å2
Dissociation area: 14,259.6 Å2
Dissociation energy (ΔGdiss): 230.53 kcal/mol
Dissociation entropy (TΔSdiss): 49.59 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-190453

Macromolecules

Mucolipin-1
Chains: A, B, C, D
Length: 580 amino acids
Theoretical weight: 65.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9GZU1 (Residues: 1-580; Coverage: 100%)
Gene names: MCOLN1, ML4, MSTP080, TRPML1
Pfam:
InterPro:
Mucolipin-1 in PDB entry 6e7z, assembly 1, front view.
Mucolipin-1 in PDB entry 6e7z, assembly 1, side view.
Mucolipin-1 in PDB entry 6e7z, assembly 1, top view.
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