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Crystal structure of the wild-type heterocomplex between coil 1B domains of human intermediate filament proteins keratin 1 (KRT1) and keratin 10 (KRT10)

X-ray diffraction
2.983Å resolution
PDB entry 6ec0 coloured by chain, front view.
PDB entry 6ec0 coloured by chain, side view.
PDB entry 6ec0 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Keratin, type I cytoskeletal 10 and Keratin, type II cytoskeletal 1
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Multimeric state: hetero tetramer
Accessible surface area: 27502.56 Å2
Buried surface area: 16107.9 Å2
Dissociation area: 2,111.21 Å2
Dissociation energy (ΔGdiss): 23.75 kcal/mol
Dissociation entropy (TΔSdiss): 14.3 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-124846

Macromolecules

Keratin, type II cytoskeletal 1
Chain: A
Length: 107 amino acids
Theoretical weight: 12.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: H6VRG1 (Residues: 227-332; Coverage: 16%)
Gene name: KRT1
Pfam: Intermediate filament protein
InterPro: Intermediate filament, rod domain
Keratin, type II cytoskeletal 1 in PDB entry 6ec0, assembly 1, front view.
Keratin, type II cytoskeletal 1 in PDB entry 6ec0, assembly 1, side view.
Keratin, type II cytoskeletal 1 in PDB entry 6ec0, assembly 1, top view.
PDBe-KB: UniProt Coverage View: H6VRG1  
1107102030405060708090100
 
50100
UniProt
H6VRG1
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Keratin, type I cytoskeletal 10
Chain: B
Length: 104 amino acids
Theoretical weight: 12.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P13645 (Residues: 195-296; Coverage: 18%)
Gene names: KPP, KRT10
Pfam: Intermediate filament protein
InterPro:
Keratin, type I cytoskeletal 10 in PDB entry 6ec0, assembly 1, front view.
Keratin, type I cytoskeletal 10 in PDB entry 6ec0, assembly 1, side view.
Keratin, type I cytoskeletal 10 in PDB entry 6ec0, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P13645  
1104102030405060708090100
 
50100GSDYSKYYKTIDDLKNQILNLTTDNANILLQIDNARLAADDFRLKYENEVALRQSVEADINGLRRVLDELTLTKADLEMQIESLTEELAYLKKNHEEEMKDLRN
UniProt
P13645
Chains
Domains
Secondary structure
Flexibility predictions
Ligand binding sites
Interaction interfaces
Molecule details ›

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