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Crystal structure of MMP12 in complex with carboxylic inhibitor LP165.

X-ray diffraction
1.3Å resolution
PDB entry 6eox coloured by chain, front view.
PDB entry 6eox coloured by chain, side view.
PDB entry 6eox coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Macrophage metalloelastase
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Multimeric state: monomeric
Accessible surface area: 8007.6 Å2
Buried surface area: 177.69 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153971

Macromolecules

Macrophage metalloelastase
Chain: A
Length: 159 amino acids
Theoretical weight: 17.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P39900 (Residues: 106-263; Coverage: 35%)
Gene names: HME, MMP12
Pfam: Matrixin
InterPro:
CATH: Collagenase (Catalytic Domain)
Macrophage metalloelastase in PDB entry 6eox, assembly 1, front view.
Macrophage metalloelastase in PDB entry 6eox, assembly 1, side view.
Macrophage metalloelastase in PDB entry 6eox, assembly 1, top view.
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