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X-ray structure of the proprotein convertase furin bound with the competitive inhibitor Phac-Cit-Val-Arg-Amba

X-ray diffraction
1.895Å resolution
PDB entry 6eqv coloured by chain, front view.
PDB entry 6eqv coloured by chain, side view.
PDB entry 6eqv coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Furin and peptide
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Multimeric state: hetero dimer
Accessible surface area: 17549.86 Å2
Buried surface area: 2267.32 Å2
Dissociation area: 594.64 Å2
Dissociation energy (ΔGdiss): -4.08 kcal/mol
Dissociation entropy (TΔSdiss): 6.31 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140847

Macromolecules

Furin
Chain: A
Length: 482 amino acids
Theoretical weight: 52.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P09958 (Residues: 108-574; Coverage: 61%)
Gene names: FUR, FURIN, PACE, PCSK3
Pfam:
InterPro:
CATH:
Furin in PDB entry 6eqv, assembly 1, front view.
Furin in PDB entry 6eqv, assembly 1, side view.
Furin in PDB entry 6eqv, assembly 1, top view.
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HY1-LLI-VAL-ARG-00S
Chain: D
Length: 5 amino acids
Theoretical weight: 665 Da
Source organism: synthetic construct
Expression system: Not provided
HY1-LLI-VAL-ARG-00S in PDB entry 6eqv, assembly 1, front view.
HY1-LLI-VAL-ARG-00S in PDB entry 6eqv, assembly 1, side view.
HY1-LLI-VAL-ARG-00S in PDB entry 6eqv, assembly 1, top view.
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