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Human butyrylcholinesterase in complex with thioflavine T

X-ray diffraction
2.8Å resolution
PDB entry 6esy coloured by chain, front view.
PDB entry 6esy coloured by chain, side view.
PDB entry 6esy coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cholinesterase
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Multimeric state: homo dimer
Accessible surface area: 41635.17 Å2
Buried surface area: 6538.59 Å2
Dissociation area: 670.66 Å2
Dissociation energy (ΔGdiss): -3.67 kcal/mol
Dissociation entropy (TΔSdiss): 14.51 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138983

Macromolecules

Cholinesterase
Chains: A, B
Length: 529 amino acids
Theoretical weight: 59.66 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P06276 (Residues: 29-557; Coverage: 92%)
Gene names: BCHE, CHE1
Pfam: Carboxylesterase family
InterPro:
CATH: alpha/beta hydrolase
Cholinesterase in PDB entry 6esy, assembly 1, front view.
Cholinesterase in PDB entry 6esy, assembly 1, side view.
Cholinesterase in PDB entry 6esy, assembly 1, top view.
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