› › Structure analysis

Structure of the acetoacetyl-CoA-thiolase/HMG-CoA-synthase complex from Methanothermococcus thermolithotrophicus at 2.75 A

X-ray diffraction
2.75Å resolution
PDB entry 6et9 coloured by chain, front view.
PDB entry 6et9 coloured by chain, side view.
PDB entry 6et9 coloured by chain, top view.
Source organism: Methanothermococcus thermolithotrophicus
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 3 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero dodecamer
Accessible surface area: 101543.99 Å2
Buried surface area: 57590.1 Å2
Dissociation area: 461.25 Å2
Dissociation energy (ΔGdiss): -4.24 kcal/mol
Dissociation entropy (TΔSdiss): 0.21 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-104734

Macromolecules

Acetyl-CoA acetyltransferase
Chains: A, B, C, D
Length: 392 amino acids
Theoretical weight: 41.94 KDa
Source organism: Methanothermococcus thermolithotrophicus
UniProt:
  • Canonical: A0A384E138 (Residues: 1-392; Coverage: 100%)
Pfam:
InterPro:
acetoacetyl-CoA thiolase in PDB entry 6et9, assembly 1, front view.
acetoacetyl-CoA thiolase in PDB entry 6et9, assembly 1, side view.
acetoacetyl-CoA thiolase in PDB entry 6et9, assembly 1, top view.
PDBe-KB: UniProt Coverage View: A0A384E138  
139250100150200250300350
 
100200300
UniProt
A0A384E138
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

Search similar proteins

DUF35 domain-containing scaffold protein
Chains: E, F, G, H
Length: 130 amino acids
Theoretical weight: 14.91 KDa
Source organism: Methanothermococcus thermolithotrophicus
UniProt:
  • Canonical: A0A384E139 (Residues: 1-130; Coverage: 100%)
Pfam:
InterPro:
Pfam DUF35 in PDB entry 6et9, assembly 1, front view.
Pfam DUF35 in PDB entry 6et9, assembly 1, side view.
Pfam DUF35 in PDB entry 6et9, assembly 1, top view.
PDBe-KB: UniProt Coverage View: A0A384E139  
1130102030405060708090100110120130
 
50100MVVRSWRHMKERYNLIGTRCKTCGKVYFPSRTVCPDCRRKGELEEFQLSGKGKIYTYSIVYAPPKEFNKLTPYVIAIVELEEGPKVTAQVDCDINKISIGIPVEAAFRRIKEDGKDGIISYGYKFVPITE
UniProt
A0A384E139
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

Search similar proteins

Hydroxymethylglutaryl-CoA synthase
Chains: I, J, K, L
Length: 349 amino acids
Theoretical weight: 37.52 KDa
Source organism: Methanothermococcus thermolithotrophicus
UniProt:
  • Canonical: A0A384E143 (Residues: 1-349; Coverage: 100%)
Pfam:
InterPro:
UPF0219 protein in PDB entry 6et9, assembly 1, front view.
UPF0219 protein in PDB entry 6et9, assembly 1, side view.
UPF0219 protein in PDB entry 6et9, assembly 1, top view.
PDBe-KB: UniProt Coverage View: A0A384E143  
134950100150200250300
 
100200300
UniProt
A0A384E143
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

Search similar proteins

Quick links