EC 2.7.11.17: Ca(2+)/calmodulin-dependent protein kinase
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (Ca(2+)/calmodulin-dependent)
Alternative Name(s):
- ATP:caldesmon O-phosphotransferase
- CAM PKII
- Ca(2+)/calmodulin-dependent microtubule-associated protein 2 kinase
- Ca(2+)/calmodulin-dependent protein kinase 1
- Ca(2+)/calmodulin-dependent protein kinase II
- Ca(2+)/calmodulin-dependent protein kinase IV
- Ca(2+)/calmodulin-dependent protein kinase kinase
- Ca(2+)/calmodulin-dependent protein kinase kinase beta
- CaM kinase
- CaM kinase II
- CaM-regulated serine/threonine kinase
- CaMKI
- CaMKII
- CaMKIV
- CaMKK-alpha
- CaMKK-beta
- Calcium/calmodulin-dependent protein kinase type II
- Caldesmon kinase
- Caldesmon kinase (phosphorylating)
- Calmodulin-dependent kinase II
- Microtubule-associated protein 2 kinase
- STK20
GO terms
Biochemical function:
Biological process:
- negative regulation of TORC1 signaling
- negative regulation of protein localization to nucleus
- Golgi reassembly
- regulation of synapse maturation
- regulation of ERK1 and ERK2 cascade
- ERK1 and ERK2 cascade
- establishment of Golgi localization
- negative regulation of innate immune response
- regulation of programmed cell death
- negative regulation of apoptotic process
- cellular response to glucose starvation
- tube formation
- regulation of protein stability
- lung development
- protein localization
- synaptic target recognition
- signal transduction
- protein targeting
- protein phosphorylation
- respiratory system process
- angiogenesis
- negative regulation of transcription by RNA polymerase II
Protein family (Pfam)![The deposited structure of PDB entry 6eww contains 4 copies of Pfam domain PF00244 (14-3-3 protein) in 14-3-3 protein zeta/delta. Showing 1 copy in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/6eww_1_B_Pfam_PF00244_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6eww</span> contains 4 copies of Pfam domain <span class='highlight'>PF00244 (14-3-3 protein)</span> in <span class='highlight'>14-3-3 protein zeta/delta</span>. Showing 1 copy in chain <span class='highlight'>C [auth B]</span>.")
InterPro annotations
CATH domain![The deposited structure of PDB entry 6eww contains 4 copies of CATH domain 1.20.190.20 (Delta-Endotoxin; domain 1) in 14-3-3 protein zeta/delta. Showing 1 copy in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/6eww_1_B_CATH_1.20.190.20_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6eww</span> contains 4 copies of CATH domain <span class='highlight'>1.20.190.20 (Delta-Endotoxin; domain 1)</span> in <span class='highlight'>14-3-3 protein zeta/delta</span>. Showing 1 copy in chain <span class='highlight'>C [auth B]</span>.")