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Structure of 14-3-3 zeta in complex with CaMKK2 14-3-3 binding motif

X-ray diffraction
2.679Å resolution
PDB entry 6eww coloured by chain, front view.
PDB entry 6eww coloured by chain, side view.
PDB entry 6eww coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Calcium/calmodulin-dependent protein kinase kinase 2 and 14-3-3 protein zeta/delta
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Multimeric state: hetero tetramer
Accessible surface area: 21431.59 Å2
Buried surface area: 4338.57 Å2
Dissociation area: 990.28 Å2
Dissociation energy (ΔGdiss): 2.32 kcal/mol
Dissociation entropy (TΔSdiss): 12.91 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-158983
Assembly 2
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Assembly Name: Calcium/calmodulin-dependent protein kinase kinase 2 and 14-3-3 protein zeta/delta
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Multimeric state: hetero tetramer
Accessible surface area: 21060.66 Å2
Buried surface area: 3737.6 Å2
Dissociation area: 406.75 Å2
Dissociation energy (ΔGdiss): 5.19 kcal/mol
Dissociation entropy (TΔSdiss): 6.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158983

Macromolecules

14-3-3 protein zeta/delta
Chains: A, B, C, D
Length: 232 amino acids
Theoretical weight: 26.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P63104 (Residues: 1-230; Coverage: 94%)
Gene name: YWHAZ
Pfam: 14-3-3 protein
InterPro:
CATH: 14-3-3 domain
14-3-3 protein zeta/delta in PDB entry 6eww, assembly 1, front view.
14-3-3 protein zeta/delta in PDB entry 6eww, assembly 1, side view.
14-3-3 protein zeta/delta in PDB entry 6eww, assembly 1, top view.
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Calcium/calmodulin-dependent protein kinase kinase 2
Chains: E, F, G, H
Length: 8 amino acids
Theoretical weight: 1.11 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q96RR4 (Residues: 97-104; Coverage: 1%)
Gene names: CAMKK2, CAMKKB, KIAA0787
Calcium/calmodulin-dependent protein kinase kinase 2 in PDB entry 6eww, assembly 1, front view.
Calcium/calmodulin-dependent protein kinase kinase 2 in PDB entry 6eww, assembly 1, side view.
Calcium/calmodulin-dependent protein kinase kinase 2 in PDB entry 6eww, assembly 1, top view.
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