Protein Data Bank in Europe

Chain: A
Length: 2413 amino acids
Theoretical weight: 279.87 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: P33334 (Residues: 1-2413; Coverage: 100%)

Gene names: DBF3, DNA39, PRP8, RNA8, SLT21, USA2, YHR165C
Pfam:

• PRO8NT (NUC069), PrP8 N-terminal domain
• PROCN (NUC071) domain
• RNA recognition motif of the spliceosomal PrP8
• U5-snRNA binding site 2 of PrP8
• U6-snRNA interacting domain of PrP8
• PRP8 domain IV core
• PROCT (NUC072) domain

InterPro:

• Pre-mRNA-processing-splicing factor 8
• PRO8NT domain
• PROCN domain
• RNA recognition motif, spliceosomal PrP8
• Ribonuclease H-like superfamily
• Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily
• Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding
• Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding
• PRP8 domain IV core
• Prp8 RNase domain IV, palm region
• Prp8 RNase domain IV, fingers region
• JAB1/MPN/MOV34 metalloenzyme domain
• MPN domain
• PROCT domain

Chain: C
Length: 1008 amino acids
Theoretical weight: 114.17 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: P36048 (Residues: 1-1008; Coverage: 100%)

Gene names: GIN10, SNU114, YKL173W, YKL637
Pfam:

• 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
• Elongation factor Tu GTP binding domain
• Elongation factor G, domain IV
• Elongation factor G C-terminus

InterPro:

• 116kDa U5 small nuclear ribonucleoprotein component, N-terminal
• P-loop containing nucleoside triphosphate hydrolase
• Translational (tr)-type GTP-binding domain
• Snu114, GTP-binding domain
• Translation protein, beta-barrel domain superfamily
• Translation elongation factor EFTu-like, domain 2
• EF-G domain III/V-like
• Ribosomal protein uS5 domain 2-type superfamily
• Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
• Translation elongation factor EFG/EF2, domain IV
• Elongation factor EFG, domain V-like
• 116kDa U5 small nuclear ribonucleoprotein component, C-terminal

Chain: D
Length: 278 amino acids
Theoretical weight: 32.37 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: P28320 (Residues: 1-278; Coverage: 100%)

Gene names: CWC16, YJU2, YKL095W, YKL442
Pfam: Saf4/Yju2 protein
InterPro:

• Splicing factor Yju2
• Saf4/Yju2 protein

Chain: H
Length: 577 amino acids
Theoretical weight: 67.39 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: P53333 (Residues: 1-577; Coverage: 100%)

Gene names: CWC22, YGR278W
Pfam: MA3 domain
InterPro:

• Armadillo-type fold
• MIF4G-like, type 3
• Initiation factor eIF-4 gamma, MA3

Chain: J
Length: 451 amino acids
Theoretical weight: 50.8 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: Q12417 (Residues: 1-451; Coverage: 100%)

Gene names: CWC1, NTC50, P2594, PRP46, YPL151C
Pfam: WD domain, G-beta repeat
InterPro:

• WD repeat Prp46/PLRG1-like
• WD40/YVTN repeat-like-containing domain superfamily
• WD40-repeat-containing domain superfamily
• WD40 repeat
• G-protein beta WD-40 repeat
• WD40 repeat, conserved site

Chain: K
Length: 379 amino acids
Theoretical weight: 42.55 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: P28004 (Residues: 1-379; Coverage: 100%)

Gene names: FUN20, PRP45, YAL032C
Pfam: SKIP/SNW domain
InterPro:

• SKI-interacting protein SKIP, SNW domain
• SKI-interacting protein, SKIP

Chain: L
Length: 157 amino acids
Theoretical weight: 18.48 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: P25337 (Residues: 1-157; Coverage: 100%)

Gene names: BUD31, CWC14, YCR063W, YCR63W, YCR903
Pfam: Pre-mRNA-splicing factor BUD31
InterPro:

• Pre-mRNA-splicing factor BUD31
• BUD31/G10-related, conserved site

Chain: M
Length: 339 amino acids
Theoretical weight: 38.49 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: Q12046 (Residues: 1-339; Coverage: 100%)

Gene names: CWC2, D1041, NTC40, SLC3, YDL209C
Pfam:

• Torus domain
• RNA recognition motif

InterPro:

• Torus domain
• Pre-mRNA-splicing factor Cwc2/Slt11
• Zinc finger, CCCH-type
• Nucleotide-binding alpha-beta plait domain superfamily
• RNA-binding domain superfamily
• Pre-mRNA-splicing factor Cwc2, RNA recognition motif
• RNA recognition motif domain

Chain: N
Length: 364 amino acids
Theoretical weight: 40.99 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: P38241 (Residues: 1-364; Coverage: 100%)

Gene names: ECM2, SLT11, YBR0614, YBR065C
Pfam: STL11, N-terminal
InterPro:

• Pre-mRNA-splicing factor Cwc2/Slt11
• Slt11, RNA recognition motif

Chain: O
Length: 590 amino acids
Theoretical weight: 67.83 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: Q03654 (Residues: 1-590; Coverage: 100%)

Gene names: CEF1, NTC85, YM8261.07, YMR213W
Pfam:

• Myb-like DNA-binding domain
• pre-mRNA splicing factor component

InterPro:

• Myb domain
• Pre-mRNA splicing factor component CDC5L/Cef1
• SANT/Myb domain
• Homedomain-like superfamily
• Pre-mRNA splicing factor component CDC5L/Cef1, second SANT/myb-like domain
• Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal

Chain: P
Length: 175 amino acids
Theoretical weight: 19.97 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: Q03772 (Residues: 1-175; Coverage: 100%)

Gene names: CWC15, YD8358.17, YDR163W
Pfam: Cwf15/Cwc15 cell cycle control protein
InterPro: Pre-mRNA-splicing factor Cwf15/Cwc15

Chain: R
Length: 135 amino acids
Theoretical weight: 15.79 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: Q03375 (Residues: 1-135; Coverage: 100%)

Gene names: CWC21, YDR482C
Pfam: cwf21 domain
InterPro: mRNA splicing factor Cwf21 domain

Chain: S
Length: 687 amino acids
Theoretical weight: 82.56 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: Q12309 (Residues: 1-687; Coverage: 100%)

Gene names: CLF1, L2952, NTC77, SYF3, YLR117C
Pfam: Suppressor of forked protein (Suf)
InterPro:

• Pre-mRNA-splicing factor Syf1-like
• HAT (Half-A-TPR) repeat
• Tetratricopeptide-like helical domain superfamily

Chain: T
Length: 859 amino acids
Theoretical weight: 100.36 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: Q04048 (Residues: 1-859; Coverage: 100%)

Gene names: NTC90, SYF1, YDR416W
Pfam: Suppressor of forked protein (Suf)
InterPro:

• Pre-mRNA-splicing factor Syf1-like
• HAT (Half-A-TPR) repeat
• Tetratricopeptide-like helical domain superfamily

Chain: V
Length: 1145 amino acids
Theoretical weight: 130.19 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: P24384 (Residues: 1-1145; Coverage: 100%)

Gene names: PRP22, YER013W
Pfam:

• S1 RNA binding domain
• DEAD/DEAH box helicase
• Helicase conserved C-terminal domain
• Helicase associated domain (HA2), winged-helix
• Helicase associated domain (HA2), ratchet-like
• Oligonucleotide/oligosaccharide-binding (OB)-fold

InterPro:

• P-loop containing nucleoside triphosphate hydrolase
• Nucleic acid-binding, OB-fold
• S1 domain
• DHX8/ Prp22, DEXH-box helicase domain
• Helicase superfamily 1/2, ATP-binding domain
• DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
• Helicase, C-terminal domain-like
• Helicase-associated domain
• DEAD-box helicase, OB fold

Chain: W
Length: 238 amino acids
Theoretical weight: 27.23 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: Q08963 (Residues: 1-238; Coverage: 100%)

Gene names: LEA1, YPL213W
Pfam: Leucine-rich repeat
InterPro:

• U2 small nuclear ribonucleoprotein A'
• Leucine-rich repeat domain superfamily
• Leucine-rich repeat
• U2A'/phosphoprotein 32 family A, C-terminal

Chain: X
Length: 95 amino acids
Theoretical weight: 8.1 KDa
Source organism: Saccharomyces cerevisiae S288C

Chain: Y
Length: 111 amino acids
Theoretical weight: 12.85 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: P40567 (Residues: 1-111; Coverage: 100%)

Gene names: MSL1, YIB9W, YIR009W
Pfam: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
InterPro:

• Nucleotide-binding alpha-beta plait domain superfamily
• RNA-binding domain superfamily
• RNA recognition motif domain

CATH: Alpha-Beta Plaits

Chain: a
Length: 251 amino acids
Theoretical weight: 28.41 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: P33411 (Residues: 1-251; Coverage: 100%)

Gene names: PRP18, YGR006W
Pfam: Prp18 domain
InterPro:

• Pre-mRNA-splicing factor 18
• Prp18

Chains: b, k
Length: 196 amino acids
Theoretical weight: 22.43 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: P40018 (Residues: 1-196; Coverage: 100%)

Gene names: SMB1, YER029C
Pfam: LSM domain
InterPro:

• Sm domain
• Sm domain, eukaryotic/archaea-type
• LSM domain superfamily

Chain: c
Length: 382 amino acids
Theoretical weight: 44.72 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: Q02775 (Residues: 1-382; Coverage: 100%)

Gene names: D4483, SLT17, SLU7, YDR088C
Pfam: Pre-mRNA splicing Prp18-interacting factor
InterPro:

• Pre-mRNA-splicing factor SLU7
• Zinc finger, CCHC-type superfamily
• Zinc finger, CCHC-type
• Pre-mRNA-splicing factor SLU7 domain

Chains: d, n
Length: 101 amino acids
Theoretical weight: 11.24 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: P43321 (Residues: 1-101; Coverage: 100%)

Gene names: L9634.6, SMD3, YLR147C
Pfam: LSM domain
InterPro:

• Sm domain
• Sm domain, eukaryotic/archaea-type
• LSM domain superfamily
• Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3
• Small nuclear ribonucleoprotein Sm D3

CATH: SH3 type barrels.

Chains: e, p
Length: 94 amino acids
Theoretical weight: 10.39 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: Q12330 (Residues: 1-94; Coverage: 100%)

Gene names: SME1, YOR159C
Pfam: LSM domain
InterPro:

• Sm domain
• Sm domain, eukaryotic/archaea-type
• LSM domain superfamily
• Small nuclear ribonucleoprotein E

CATH: SH3 type barrels.

Chains: f, q
Length: 86 amino acids
Theoretical weight: 9.67 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: P54999 (Residues: 1-86; Coverage: 100%)

Gene names: P9705.4, SMX3, YPR182W
Pfam: LSM domain
InterPro:

• Sm domain
• Sm domain, eukaryotic/archaea-type
• LSM domain superfamily
• Sm-like protein Lsm6/SmF
• Small nuclear ribonucleoprotein F

CATH: SH3 type barrels.

Chains: g, r
Length: 77 amino acids
Theoretical weight: 8.49 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: P40204 (Residues: 1-77; Coverage: 100%)

Gene names: SMX2, SNP2, YFL017Bw, YFL017W-A
Pfam: LSM domain
InterPro:

• Sm domain
• Sm domain, eukaryotic/archaea-type
• LSM domain superfamily
• Small nuclear ribonucleoprotein G
• Sm-like protein Lsm7/SmG

CATH: SH3 type barrels.

Chains: h, l
Length: 146 amino acids
Theoretical weight: 16.3 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: Q02260 (Residues: 1-146; Coverage: 100%)

Gene names: SMD1, YGR074W
Pfam: LSM domain
InterPro:

• Sm domain
• Sm domain, eukaryotic/archaea-type
• LSM domain superfamily
• Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3
• Small nuclear ribonucleoprotein D1

Chains: j, m
Length: 110 amino acids
Theoretical weight: 12.88 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: Q06217 (Residues: 1-110; Coverage: 100%)

Gene names: L9328.5, SMD2, YLR275W
Pfam: LSM domain
InterPro:

• Sm domain
• Sm domain, eukaryotic/archaea-type
• LSM domain superfamily
• Small nuclear ribonucleoprotein Sm D2

CATH: SH3 type barrels.

Chain: o
Length: 455 amino acids
Theoretical weight: 52.13 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: P40968 (Residues: 1-455; Coverage: 100%)

Gene names: CDC40, D9481.11, PRP17, SLU4, XRS2, YDR364C
Pfam: WD domain, G-beta repeat
InterPro:

• WD40/YVTN repeat-like-containing domain superfamily
• WD40-repeat-containing domain superfamily
• WD40 repeat
• G-protein beta WD-40 repeat
• Pre-mRNA-processing factor 17

Chain: s
Length: 175 amino acids
Theoretical weight: 20.74 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: Q06091 (Residues: 1-175; Coverage: 100%)

Gene names: NTC25, SNT309, YPR101W

Chains: t, u, v, w
Length: 503 amino acids
Theoretical weight: 56.63 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: P32523 (Residues: 1-503; Coverage: 100%)

Gene names: PRP19, PSO4, YLL036C
Pfam: Prp19/Pso4-like
InterPro:

• WD40/YVTN repeat-like-containing domain superfamily
• U-box domain
• Zinc finger, RING/FYVE/PHD-type
• Pre-mRNA-splicing factor 19, coiled-coil region
• Quinoprotein alcohol dehydrogenase-like superfamily
• Pre-mRNA-processing factor 19

Chain: y
Length: 215 amino acids
Theoretical weight: 24.85 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:

• Canonical: P53277 (Residues: 1-215; Coverage: 100%)

Gene names: NTC31, SYF2, YGR129W
Pfam: SYF2 splicing factor
InterPro: mRNA splicing factor SYF2