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Molecular recognition of wood polyphenols by phase II detoxification enzymes of the white rot Trametes versicolor.

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Schwartz M, Perrot T, Aubert E, Dumarçay S, Favier F, Gérardin P, Morel-Rouhier M, Mulliert G, Saiag F, Didierjean C, Gelhaye E
OpenAccess logo Sci Rep 8 8472 (2018)
Related entries: 6f43, 6f4b, 6f4f, 6f51, 6f66, 6f67, 6f68, 6f69, 6f6a, 6f70, 6f71, 6ht6

Cited: 14 times
EuropePMC logo PMID: 29855494

Abstract

Wood decay fungi have complex detoxification systems that enable them to cope with secondary metabolites produced by plants. Although the number of genes encoding for glutathione transferases is especially expanded in lignolytic fungi, little is known about their target molecules. In this study, by combining biochemical, enzymatic and structural approaches, interactions between polyphenols and six glutathione transferases from the white-rot fungus Trametes versicolor have been demonstrated. Two isoforms, named TvGSTO3S and TvGSTO6S have been deeply studied at the structural level. Each isoform shows two distinct ligand-binding sites, a narrow L-site at the dimer interface and a peculiar deep hydrophobic H-site. In TvGSTO3S, the latter appears optimized for aromatic ligand binding such as hydroxybenzophenones. Affinity crystallography revealed that this H-site retains the flavonoid dihydrowogonin from a partially purified wild-cherry extract. Besides, TvGSTO6S binds two molecules of the flavonoid naringenin in the L-site. These data suggest that TvGSTO isoforms could interact with plant polyphenols released during wood degradation.

Articles - 6f4k mentioned but not cited (2)

  1. Molecular recognition of wood polyphenols by phase II detoxification enzymes of the white rot Trametes versicolor. Schwartz M, Perrot T, Aubert E, Dumarçay S, Favier F, Gérardin P, Morel-Rouhier M, Mulliert G, Saiag F, Didierjean C, Gelhaye E. Sci Rep 8 8472 (2018)
  2. The structure of Trametes versicolor glutathione transferase Omega 3S bound to its conjugation product glutathionyl-phenethylthiocarbamate reveals plasticity of its active site. Schwartz M, Perrot T, Morel-Rouhier M, Mulliert G, Gelhaye E, Didierjean C, Favier F. Protein Sci 28 1143-1150 (2019)


Reviews citing this publication (4)

  1. Modes-of-action of antifungal compounds: Stressors and (target-site-specific) toxins, toxicants, or toxin-stressors. Noel D, Hallsworth JE, Gelhaye E, Darnet S, Sormani R, Morel-Rouhier M. Microb Biotechnol 16 1438-1455 (2023)
  2. The Glutathione System: A Journey from Cyanobacteria to Higher Eukaryotes. Cassier-Chauvat C, Marceau F, Farci S, Ouchane S, Chauvat F. Antioxidants (Basel) 12 1199 (2023)
  3. Fungal bioassays for environmental monitoring. Soares DMM, Procópio DP, Zamuner CK, Nóbrega BB, Bettim MR, de Rezende G, Lopes PM, Pereira ABD, Bechara EJH, Oliveira AG, Freire RS, Stevani CV. Front Bioeng Biotechnol 10 954579 (2022)
  4. Biotechnological methods to remove microplastics: a review. Anand U, Dey S, Bontempi E, Ducoli S, Vethaak AD, Dey A, Federici S. Environ Chem Lett 21 1787-1810 (2023)

Articles citing this publication (8)

  1. Characterization of rat glutathione transferases in olfactory epithelium and mucus. Heydel JM, Menetrier F, Belloir C, Canon F, Faure P, Lirussi F, Chavanne E, Saliou JM, Artur Y, Canivenc-Lavier MC, Briand L, Neiers F. PLoS One 14 e0220259 (2019)
  2. Is there a role for tau glutathione transferases in tetrapyrrole metabolism and retrograde signalling in plants? Sylvestre-Gonon E, Schwartz M, Girardet JM, Hecker A, Rouhier N. Philos Trans R Soc Lond B Biol Sci 375 20190404 (2020)
  3. A First Insight into North American Plant Pathogenic Fungi Armillaria Sinapina Transcriptome. Fradj N, de Montigny N, Mérindol N, Awwad F, Boumghar Y, Germain H, Desgagné-Penix I. Biology (Basel) 9 E153 (2020)
  4. A reverse chemical ecology approach to explore wood natural durability. Perrot T, Salzet G, Amusant N, Beauchene J, Gérardin P, Dumarçay S, Sormani R, Morel-Rouhier M, Gelhaye E. Microb Biotechnol 13 1673-1677 (2020)
  5. Biochemical and Structural Characterization of Chi-Class Glutathione Transferases: A Snapshot on the Glutathione Transferase Encoded by sll0067 Gene in the Cyanobacterium Synechocystis sp. Strain PCC 6803. Mocchetti E, Morette L, Mulliert G, Mathiot S, Guillot B, Dehez F, Chauvat F, Cassier-Chauvat C, Brochier-Armanet C, Didierjean C, Hecker A. Biomolecules 12 1466 (2022)
  6. Biochemical and Structural Insights on the Poplar Tau Glutathione Transferase GSTU19 and 20 Paralogs Binding Flavonoids. Sylvestre-Gonon E, Morette L, Viloria M, Mathiot S, Boutilliat A, Favier F, Rouhier N, Didierjean C, Hecker A. Front Mol Biosci 9 958586 (2022)
  7. Qualitative metabolomics-based characterization of a phenolic UDP-xylosyltransferase with a broad substrate spectrum from Lentinus brumalis. Jeong E, Kim W, Son S, Yang S, Gwon D, Hong J, Cho Y, Jang CY, Steinegger M, Lim YW, Kang KB. Proc Natl Acad Sci U S A 120 e2301007120 (2023)
  8. Press water from the mechanical drying of Douglas-fir wood chips has multiple beneficial effects on lignocellulolytic fungi. Reppke MJ, Gerstner R, Windeisen-Holzhauser E, Richter K, Benz JP. Fungal Biol Biotechnol 9 10 (2022)


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