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A mechanism for the activation of the influenza virus transcriptase

X-ray diffraction
4.14Å resolution
PDB entry 6f5p coloured by chain, front view.
PDB entry 6f5p coloured by chain, side view.
PDB entry 6f5p coloured by chain, top view.
Source organisms:
Assembly composition:
hetero octamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero octamer
Accessible surface area: 182026.6 Å2
Buried surface area: 77745.9 Å2
Dissociation area: 2,142.81 Å2
Dissociation energy (ΔGdiss): -9.38 kcal/mol
Dissociation entropy (TΔSdiss): 24.24 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-279871

Macromolecules

Polymerase acidic protein
Chains: A, D
Length: 709 amino acids
Theoretical weight: 82.03 KDa
Source organism: Influenza C virus (C/Johannesburg/1/66)
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9IMP5 (Residues: 1-709; Coverage: 100%)
Gene names: P3, PA
Pfam: Influenza RNA-dependent RNA polymerase subunit PA
InterPro:
Polymerase acidic protein in PDB entry 6f5p, assembly 1, front view.
Polymerase acidic protein in PDB entry 6f5p, assembly 1, side view.
Polymerase acidic protein in PDB entry 6f5p, assembly 1, top view.
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RNA-directed RNA polymerase catalytic subunit
Chains: B, C
Length: 754 amino acids
Theoretical weight: 86.15 KDa
Source organism: Influenza C virus (C/Johannesburg/1/66)
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9IMP4 (Residues: 1-754; Coverage: 100%)
Gene name: PB1
Pfam: Influenza RNA-dependent RNA polymerase subunit PB1
InterPro:
RNA-directed RNA polymerase catalytic subunit in PDB entry 6f5p, assembly 1, front view.
RNA-directed RNA polymerase catalytic subunit in PDB entry 6f5p, assembly 1, side view.
RNA-directed RNA polymerase catalytic subunit in PDB entry 6f5p, assembly 1, top view.
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Polymerase basic protein 2
Chains: E, F
Length: 774 amino acids
Theoretical weight: 87.95 KDa
Source organism: Influenza C virus (C/Johannesburg/1/66)
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9IMP3 (Residues: 1-774; Coverage: 100%)
Gene name: PB2
Pfam:
InterPro: Influenza RNA-dependent RNA polymerase subunit PB2
Polymerase basic protein 2 in PDB entry 6f5p, assembly 1, front view.
Polymerase basic protein 2 in PDB entry 6f5p, assembly 1, side view.
Polymerase basic protein 2 in PDB entry 6f5p, assembly 1, top view.
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DNA-directed RNA polymerase II subunit RPB1
Chain: G
Length: 28 amino acids
Theoretical weight: 3.22 KDa
Source organism: Fopius arisanus
Expression system: synthetic construct
UniProt:
  • Canonical: P24928 (Residues: 1713-1740; Coverage: 1%)
Gene names: POLR2, POLR2A
Pfam: RNA polymerase Rpb1 C-terminal repeat
InterPro: RNA polymerase II, heptapeptide repeat, eukaryotic
DNA-directed RNA polymerase subunit in PDB entry 6f5p, assembly 1, front view.
DNA-directed RNA polymerase subunit in PDB entry 6f5p, assembly 1, side view.
DNA-directed RNA polymerase subunit in PDB entry 6f5p, assembly 1, top view.
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ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA
Chain: H
Length: 10 amino acids
Theoretical weight: 729 Da
Source organism: Homo sapiens
Expression system: Not provided
ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA in PDB entry 6f5p, assembly 1, front view.
ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA in PDB entry 6f5p, assembly 1, side view.
ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA in PDB entry 6f5p, assembly 1, top view.
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