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Crystal structure of the small alarmone synthethase 2 from Staphylococcus aureus bound to AMPCPP

Source organism: Staphylococcus aureus
Biochemical function: metal ion binding
Biological process: guanosine tetraphosphate biosynthetic process
Cellular component: not assigned

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EC 2.7.6.5: GTP diphosphokinase

Reaction catalysed:
ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate
Systematic name:
ATP:GTP 3'-diphosphotransferase
Alternative Name(s):
  • (p)ppGpp synthetase I
  • (p)ppGpp synthetase II
  • ATP-GTP 3'-diphosphotransferase
  • GPSI
  • GPSII
  • GTP pyrophosphokinase
  • Guanosine 3',5'-polyphosphate synthase
  • Guanosine 5',3'-polyphosphate synthetase
  • Guanosine pentaphosphate synthetase
  • Stringent factor
  • ppGpp synthetase I

GO terms

Sequence family

Pfam Protein family (Pfam)
PF04607
Domain description: Region found in RelA / SpoT proteins
Occurring in:
  1. RelA/SpoT domain-containing protein
The deposited structure of PDB entry 6fgx contains 2 copies of Pfam domain PF04607 (Region found in RelA / SpoT proteins) in RelA/SpoT domain-containing protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR007685
Domain description: RelA/SpoT
Occurring in:
  1. RelA/SpoT domain-containing protein
IPR043519
Domain description: Nucleotidyltransferase superfamily
Occurring in:
  1. RelA/SpoT domain-containing protein

Structure domain

CATH CATH domain
3.30.460.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Beta Polymerase; domain 2
Homology: Beta Polymerase, domain 2
Occurring in:
  1. RelA/SpoT domain-containing protein
The deposited structure of PDB entry 6fgx contains 2 copies of CATH domain 3.30.460.10 (Beta Polymerase; domain 2) in RelA/SpoT domain-containing protein. Showing 1 copy in chain A.

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