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Crystal structure of ERK2 in complex with an adenosine derivative

X-ray diffraction
1.85Å resolution
PDB entry 6fjb coloured by chain, front view.
PDB entry 6fjb coloured by chain, side view.
PDB entry 6fjb coloured by chain, top view.
Source organism: Rattus norvegicus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mitogen-activated protein kinase 1
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Multimeric state: monomeric
Accessible surface area: 16167.31 Å2
Buried surface area: 197.1 Å2
Dissociation area: 98.55 Å2
Dissociation energy (ΔGdiss): 15.29 kcal/mol
Dissociation entropy (TΔSdiss): 0.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158941

Macromolecules

Mitogen-activated protein kinase 1
Chain: A
Length: 364 amino acids
Theoretical weight: 42.24 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P63086 (Residues: 1-358; Coverage: 100%)
Gene names: Erk2, Mapk, Mapk1, Prkm1
Pfam: Protein kinase domain
InterPro:
CATH:
Mitogen-activated protein kinase 1 in PDB entry 6fjb, assembly 1, front view.
Mitogen-activated protein kinase 1 in PDB entry 6fjb, assembly 1, side view.
Mitogen-activated protein kinase 1 in PDB entry 6fjb, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P63086  
136450100150200250300350
 
100200300
UniProt
P63086
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