EC 2.7.11.24: Mitogen-activated protein kinase
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (MAPKK-activated)
Alternative Name(s):
- C-Jun N-terminal kinase
- Dp38
- ERK
- ERK1
- ERK2
- Extracellular signal-regulated kinase
- JNK
- JNK3-alpha-1
- LeMPK3
- MAP kinase
- MAP-2 kinase
- MAPK
- MBP kinase I
- MBP kinase II
- Microtubule-associated protein 2 kinase
- Microtubule-associated protein kinase
- Myelin basic protein kinase
- P38-2
- P38-delta
- P42 mitogen-activated protein kinase
- P42(mapk)
- P44mpk
- PMK-1
- PMK-2
- PMK-3
- Pp42
- Pp44(mapk)
- SAPK
- STK26
- Stress-activated protein kinase
GO terms
Biochemical function:
- protein serine kinase activity
- identical protein binding
- mitogen-activated protein kinase kinase kinase binding
- phosphatase binding
- protein kinase binding
- transferase activity
- kinase activity
- RNA polymerase II CTD heptapeptide repeat kinase activity
- ATP binding
- protein binding
- MAP kinase activity
- protein serine/threonine kinase activity
- protein kinase activity
- double-stranded DNA binding
- phosphotyrosine residue binding
- nucleotide binding
Biological process:
- regulation of early endosome to late endosome transport
- cellular response to insulin-like growth factor stimulus
- positive regulation of macrophage proliferation
- response to alcohol
- cellular response to toxic substance
- regulation of Golgi inheritance
- caveolin-mediated endocytosis
- cellular response to prostaglandin E stimulus
- cellular response to epidermal growth factor stimulus
- cellular response to tumor necrosis factor
- cellular response to cAMP
- response to epidermal growth factor
- ERK1 and ERK2 cascade
- cellular response to methionine
- cardiac neural crest cell development involved in heart development
- labyrinthine layer blood vessel development
- trachea formation
- lung morphogenesis
- face development
- long-term synaptic potentiation
- positive regulation of cardiac muscle cell proliferation
- Bergmann glial cell differentiation
- regulation of cytoskeleton organization
- stress-activated MAPK cascade
- B cell receptor signaling pathway
- T cell receptor signaling pathway
- progesterone receptor signaling pathway
- thymus development
- insulin-like growth factor receptor signaling pathway
- decidualization
- positive regulation of DNA-templated transcription
- positive regulation of translation
- negative regulation of cell differentiation
- positive regulation of cholesterol biosynthetic process
- estrous cycle
- response to estrogen
- steroid hormone receptor signaling pathway
- response to exogenous dsRNA
- myelination
- response to hydrogen peroxide
- outer ear morphogenesis
- positive regulation of protein import into nucleus
- response to cocaine
- ERBB2-ERBB3 signaling pathway
- ERBB signaling pathway
- cellular response to platelet-derived growth factor stimulus
- intracellular signal transduction
- response to nicotine
- cellular response to amino acid starvation
- mammary gland epithelial cell proliferation
- response to testosterone
- regulation of stress-activated MAPK cascade
- response to lipopolysaccharide
- response to estradiol
- positive regulation of telomere maintenance
- lipopolysaccharide-mediated signaling pathway
- regulation of protein stability
- thyroid gland development
- regulation of cellular pH
- androgen receptor signaling pathway
- positive regulation of cell migration
- regulation of ossification
- cytosine metabolic process
- sensory perception of pain
- peptidyl-threonine phosphorylation
- peptidyl-serine phosphorylation
- diadenosine tetraphosphate biosynthetic process
- Schwann cell development
- neural crest cell development
- positive regulation of macrophage chemotaxis
- animal organ morphogenesis
- response to toxic substance
- insulin receptor signaling pathway
- positive regulation of cell population proliferation
- heart development
- epidermal growth factor receptor signaling pathway
- cell surface receptor signaling pathway
- DNA damage response
- apoptotic process
- protein phosphorylation
- regulation of transcription by RNA polymerase II
- MAPK cascade
Cellular component:
- mitotic spindle
- anchoring junction
- perikaryon
- protein-containing complex
- dendrite cytoplasm
- pseudopodium
- axon
- membrane
- postsynaptic density
- focal adhesion
- caveola
- plasma membrane
- cytoskeleton
- cytosol
- spindle
- centrosome
- Golgi apparatus
- late endosome
- early endosome
- mitochondrion
- cytoplasm
- nucleoplasm
- nucleus
Sequence family
Protein family (Pfam)
InterPro annotations
Structure domains
CATH domains
3.30.200.20
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Phosphorylase Kinase; domain 1
Homology:
Phosphorylase Kinase; domain 1
Occurring in:
