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Complement factor D in complex with the inhibitor 3-((3-((3-(aminomethyl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)phenol

X-ray diffraction
2.21Å resolution
PDB entry 6fug coloured by chain, front view.
PDB entry 6fug coloured by chain, side view.
PDB entry 6fug coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Complement factor D
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Multimeric state: monomeric
Accessible surface area: 9889.53 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133224
Assembly 2
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Assembly Name: Complement factor D
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Multimeric state: monomeric
Accessible surface area: 9864.01 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133224
Assembly 3
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Assembly Name: Complement factor D
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Multimeric state: monomeric
Accessible surface area: 10082.16 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133224
Assembly 4
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Assembly Name: Complement factor D
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Multimeric state: monomeric
Accessible surface area: 9850.45 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133224
Assembly 5
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Assembly Name: Complement factor D
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Multimeric state: monomeric
Accessible surface area: 9821.88 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133224
Assembly 6
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Assembly Name: Complement factor D
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Multimeric state: monomeric
Accessible surface area: 9836.85 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133224

Macromolecules

Complement factor D
Chains: A, B, C, D, E, F
Length: 232 amino acids
Theoretical weight: 24.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00746 (Residues: 26-253; Coverage: 98%)
Gene names: CFD, DF, PFD
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
Complement factor D in PDB entry 6fug, assembly 1, front view.
Complement factor D in PDB entry 6fug, assembly 1, side view.
Complement factor D in PDB entry 6fug, assembly 1, top view.
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