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MHC A02 Allele presenting MTSAIGILVP

X-ray diffraction
2.45Å resolution
PDB entry 6g3j coloured by chain, front view.
PDB entry 6g3j coloured by chain, side view.
PDB entry 6g3j coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1
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Multimeric state: hetero trimer
Accessible surface area: 19351.95 Å2
Buried surface area: 4383.53 Å2
Dissociation area: 1,313.68 Å2
Dissociation energy (ΔGdiss): 6.3 kcal/mol
Dissociation entropy (TΔSdiss): 12.1 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137795
Assembly 2 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 19368.55 Å2
Buried surface area: 4295.15 Å2
Dissociation area: 1,267.76 Å2
Dissociation energy (ΔGdiss): 6.27 kcal/mol
Dissociation entropy (TΔSdiss): 12.09 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137795

Macromolecules

HLA class I histocompatibility antigen, A alpha chain
Chains: A, D
Length: 276 amino acids
Theoretical weight: 31.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Pfam:
InterPro:
CATH:
HLA class I histocompatibility antigen, A alpha chain in PDB entry 6g3j, assembly 2, front view.
HLA class I histocompatibility antigen, A alpha chain in PDB entry 6g3j, assembly 2, side view.
HLA class I histocompatibility antigen, A alpha chain in PDB entry 6g3j, assembly 2, top view.
PDBe-KB: UniProt Coverage View: P04439  
127620406080100120140160180200220240260
 
100200
UniProt
P04439
Chains
Domains
Secondary structure
Flexibility predictions
Interaction interfaces
Sequence conservation
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Beta-2-microglobulin
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
Beta-2-microglobulin in PDB entry 6g3j, assembly 2, front view.
Beta-2-microglobulin in PDB entry 6g3j, assembly 2, side view.
Beta-2-microglobulin in PDB entry 6g3j, assembly 2, top view.
PDBe-KB: UniProt Coverage View: P61769  
1100102030405060708090100
 
50100MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM
UniProt
P61769
Chains
Domains
Secondary structure
Flexibility predictions
Interaction interfaces
Sequence conservation
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MET-THR-SER-ALA-ILE-GLY-ILE-LEU-PRO-VAL
Chains: C, F
Length: 10 amino acids
Theoretical weight: 1 KDa
Source organism: Homo sapiens
Expression system: Not provided
MET-THR-SER-ALA-ILE-GLY-ILE-LEU-PRO-VAL in PDB entry 6g3j, assembly 2, front view.
MET-THR-SER-ALA-ILE-GLY-ILE-LEU-PRO-VAL in PDB entry 6g3j, assembly 2, side view.
MET-THR-SER-ALA-ILE-GLY-ILE-LEU-PRO-VAL in PDB entry 6g3j, assembly 2, top view.
11012345678910
 
510MTSAIGILPV
Chains
Chain C (auth C)
Chain F (auth F)
Flexibility predictions
Interaction interfaces
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