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Crystal structure of human glutaminyl cyclase variant Y115E-Y117E in complex with SEN177

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: protein modification process
Cellular component: ficolin-1-rich granule lumen

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EC 2.3.2.5: Glutaminyl-peptide cyclotransferase

Reaction catalysed:
L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH(3)
Systematic name:
L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing)
Alternative Name(s):
  • Glutaminyl cyclase
  • Glutaminyl-tRNA cyclotransferase
  • Glutaminyl-transfer ribonucleate cyclotransferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF04389
Domain description: Peptidase family M28
Occurring in:
  1. Glutaminyl-peptide cyclotransferase
The deposited structure of PDB entry 6gbx contains 3 copies of Pfam domain PF04389 (Peptidase family M28) in Glutaminyl-peptide cyclotransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR007484
Domain description: Peptidase M28
Occurring in:
  1. Glutaminyl-peptide cyclotransferase
IPR037457
Domain description: M28 Zn-Peptidase Glutaminyl Cyclase
Occurring in:
  1. Glutaminyl-peptide cyclotransferase
IPR040234
Domain description: Glutaminyl-peptide cyclotransferase-like
Occurring in:
  1. Glutaminyl-peptide cyclotransferase

Structure domain

CATH CATH domain
3.40.630.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aminopeptidase
Homology: Zn peptidases
Occurring in:
  1. Glutaminyl-peptide cyclotransferase
The deposited structure of PDB entry 6gbx contains 3 copies of CATH domain 3.40.630.10 (Aminopeptidase) in Glutaminyl-peptide cyclotransferase. Showing 1 copy in chain A.

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