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Crystal structure of human glutaminyl cyclase variant Y115E-Y117E in complex with SEN177

X-ray diffraction
1.72Å resolution
PDB entry 6gbx coloured by chain, front view.
PDB entry 6gbx coloured by chain, side view.
PDB entry 6gbx coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glutaminyl-peptide cyclotransferase
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Multimeric state: monomeric
Accessible surface area: 13520.6 Å2
Buried surface area: 1288.4 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172570
Assembly 2
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Assembly Name: Glutaminyl-peptide cyclotransferase
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Multimeric state: monomeric
Accessible surface area: 13659.32 Å2
Buried surface area: 2068.01 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172570
Assembly 3
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Assembly Name: Glutaminyl-peptide cyclotransferase
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Multimeric state: monomeric
Accessible surface area: 13585.69 Å2
Buried surface area: 1536.44 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172570

Macromolecules

Glutaminyl-peptide cyclotransferase
Chains: A, B, C
Length: 329 amino acids
Theoretical weight: 37.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16769 (Residues: 33-361; Coverage: 99%)
Gene name: QPCT
Pfam: Peptidase family M28
InterPro:
CATH: Zn peptidases
Glutaminyl-peptide cyclotransferase in PDB entry 6gbx, assembly 1, front view.
Glutaminyl-peptide cyclotransferase in PDB entry 6gbx, assembly 1, side view.
Glutaminyl-peptide cyclotransferase in PDB entry 6gbx, assembly 1, top view.
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