› 6gcw

X-ray diffraction
2Å resolution

Focal Adhesion Kinase catalytic domain in complex with irreversible inhibitor

Released:
DOI: 10.2210/pdb6gcw/pdb
PDB entry 6gcw coloured by chain, front view.
PDB entry 6gcw coloured by chain, side view.
PDB entry 6gcw coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase.
Yen-Pon E, Li B, Acebrón-Garcia-de-Eulate M, Tomkiewicz-Raulet C, Dawson J, Lietha D, Frame MC, Coumoul X, Garbay C, Etheve-Quelquejeu M, Chen H
ACS Chem Biol 13 2067-2073 (2018)
PMID: 29897729

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-554028 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Focal adhesion kinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 31.73 KDa
Source organism: Gallus gallus
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q00944 (Residues: 411-686; Coverage: 26%)
Gene names: FAK, FAK1, PTK2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand EUQ 2 x EUQ
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: P21
Unit cell:
a: 44.916Å b: 119.798Å c: 52.81Å
α: 90° β: 90.56° γ: 90°
R-values:
R R work R free
0.22 0.217 0.274
Expression system: unidentified baculovirus

Quick links

Citations

3 review citations

Drug Discovery Targeting Focal Adhesion Kinase (FAK) as a Promising Cancer Therapy.
Pang et al. (2021)
2 more