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Focal Adhesion Kinase catalytic domain in complex with irreversible inhibitor

X-ray diffraction
2Å resolution
PDB entry 6gcw coloured by chain, front view.
PDB entry 6gcw coloured by chain, side view.
PDB entry 6gcw coloured by chain, top view.
Source organism: Gallus gallus
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Focal adhesion kinase 1
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Multimeric state: homo dimer
Accessible surface area: 24379.95 Å2
Buried surface area: 1643.09 Å2
Dissociation area: 746.28 Å2
Dissociation energy (ΔGdiss): -10.4 kcal/mol
Dissociation entropy (TΔSdiss): 12.84 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169486

Macromolecules

Focal adhesion kinase 1
Chains: A, B
Length: 276 amino acids
Theoretical weight: 31.73 KDa
Source organism: Gallus gallus
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q00944 (Residues: 411-686; Coverage: 26%)
Gene names: FAK, FAK1, PTK2
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Focal adhesion kinase 1 in PDB entry 6gcw, assembly 1, front view.
Focal adhesion kinase 1 in PDB entry 6gcw, assembly 1, side view.
Focal adhesion kinase 1 in PDB entry 6gcw, assembly 1, top view.
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