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TEAD4 (216-434);Y429F COMPLEXED WITH YAP PEPTIDE (60-100) AND MYRISTOATE (COVALENTLY BOUND) AT 2.28A (P212121 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA

X-ray diffraction
2.28Å resolution
PDB entry 6gek coloured by chain, front view.
PDB entry 6gek coloured by chain, side view.
PDB entry 6gek coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Transcriptional enhancer factor TEF-3 and Transcriptional coactivator YAP1
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Multimeric state: hetero dimer
Accessible surface area: 12337.44 Å2
Buried surface area: 2993.69 Å2
Dissociation area: 1,141.69 Å2
Dissociation energy (ΔGdiss): 11.44 kcal/mol
Dissociation entropy (TΔSdiss): 10.39 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155554
Assembly 2
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Assembly Name: Transcriptional enhancer factor TEF-3 and Transcriptional coactivator YAP1
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Multimeric state: hetero dimer
Accessible surface area: 12744.06 Å2
Buried surface area: 2946.6 Å2
Dissociation area: 1,110.73 Å2
Dissociation energy (ΔGdiss): 9.89 kcal/mol
Dissociation entropy (TΔSdiss): 10.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155554

Macromolecules

Transcriptional enhancer factor TEF-3
Chains: A, B
Length: 219 amino acids
Theoretical weight: 25.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q15561 (Residues: 216-434; Coverage: 51%)
Gene names: RTEF1, TCF13L1, TEAD4, TEF3
Pfam: YAP binding domain
InterPro: YAP binding domain
CATH: Coagulation Factor XIII; Chain A, domain 1
Transcriptional enhancer factor TEF-3 in PDB entry 6gek, assembly 1, front view.
Transcriptional enhancer factor TEF-3 in PDB entry 6gek, assembly 1, side view.
Transcriptional enhancer factor TEF-3 in PDB entry 6gek, assembly 1, top view.
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Transcriptional coactivator YAP1
Chains: L, M
Length: 41 amino acids
Theoretical weight: 4.65 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P46937 (Residues: 60-100; Coverage: 8%)
Gene names: YAP1, YAP65
Pfam: Omega loop, TEAD interating region 3
Transcriptional coactivator YAP1 in PDB entry 6gek, assembly 1, front view.
Transcriptional coactivator YAP1 in PDB entry 6gek, assembly 1, side view.
Transcriptional coactivator YAP1 in PDB entry 6gek, assembly 1, top view.
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