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Translation initiation factor 4E in complex with trinucleotide mRNA 5' cap (m7GpppApG)

X-ray diffraction
2.068Å resolution
PDB entry 6gkj coloured by chain, front view.
PDB entry 6gkj coloured by chain, side view.
PDB entry 6gkj coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Eukaryotic translation initiation factor 4E
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Multimeric state: monomeric
Accessible surface area: 9481.71 Å2
Buried surface area: 908.01 Å2
Dissociation area: 141.08 Å2
Dissociation energy (ΔGdiss): 1.59 kcal/mol
Dissociation entropy (TΔSdiss): 0.86 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158938
Assembly 2
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Assembly Name: Eukaryotic translation initiation factor 4E
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Multimeric state: monomeric
Accessible surface area: 9418.26 Å2
Buried surface area: 899.26 Å2
Dissociation area: 136.57 Å2
Dissociation energy (ΔGdiss): 1.92 kcal/mol
Dissociation entropy (TΔSdiss): 0.82 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158938
Assembly 3
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Assembly Name: Eukaryotic translation initiation factor 4E
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Multimeric state: monomeric
Accessible surface area: 9476.46 Å2
Buried surface area: 431.73 Å2
Dissociation area: 215.86 Å2
Dissociation energy (ΔGdiss): -2.14 kcal/mol
Dissociation entropy (TΔSdiss): 5.31 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158938
Assembly 4
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Assembly Name: Eukaryotic translation initiation factor 4E
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Multimeric state: monomeric
Accessible surface area: 9282.26 Å2
Buried surface area: 607.64 Å2
Dissociation area: 303.82 Å2
Dissociation energy (ΔGdiss): -0.62 kcal/mol
Dissociation entropy (TΔSdiss): 5.34 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158938

Macromolecules

Eukaryotic translation initiation factor 4E
Chains: A, B, C, D
Length: 190 amino acids
Theoretical weight: 22.15 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P63073 (Residues: 28-217; Coverage: 88%)
Gene name: Eif4e
Pfam: Eukaryotic initiation factor 4E
InterPro:
Eukaryotic translation initiation factor 4E in PDB entry 6gkj, assembly 1, front view.
Eukaryotic translation initiation factor 4E in PDB entry 6gkj, assembly 1, side view.
Eukaryotic translation initiation factor 4E in PDB entry 6gkj, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P63073  
119020406080100120140160180
 
50100150
UniProt
P63073
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Secondary structure
Flexibility predictions
Ligand binding sites
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